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Role of SIRT7 in aging-related diseases

Sirtuin was identified as a histone deacetylase that inhibits yeast aging. Mammals have seven types of sirtuin molecules, and these enzymes are involved in various life phenomena such as sugar and lipid metabolism, DNA repair, and aging. We found that knocking out SIRT7 ameliorated hepatic lipid accumulation. As a mechanism, SIRT7 suppresses the action of the proteolytic enzyme of the TR4 transcription factor, and when the action of SIRT7 is weakened, the amount of TR4 decreases, making it difficult for fat to accumulate in the liver (Yoshizawa, T. et al., Cell Metab., 2014). This achievement was introduced in Yomiuri Shimbun, Nishinippon Shimbun, Kumamoto Nichinichi Shimbun, NHK (TV news), and TKU (TV news). Furthermore, we have found that SIRT7 also plays an important role in bone, brain, heart, kidney, white adipose tissue and brown adipose tissue, and are currently conducting detailed analysis. Through this research, we aim to identify new lipid metabolism control mechanisms and apply them to clinical practice.

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