​2022

​

Mizutani H, Sato Y, Yamazaki M, Yoshizawa T, Ando Y, Ueda M, Yamagata K.

SIRT7 Deficiency Protects against Aβ42-Induced Apoptosis through the Regulation of NOX4-Derived Reactive Oxygen Species Production in SH-SY5Y Cells.

Int J Mol Sci.2022 23:9027. doi: 10.3390/ijms23169027.

​

2021

​

Daikuzono H, Yamazaki M, Sato Y, Takahashi T, Yamagata K.

Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes.

Biochem Biophys Res Commun2021 578:170-176.

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Akter F, Tsuyama T, Yoshizawa T, Sobuz SU, Yamagata K.

SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARγ2.

J Diabetes Investig.2021 12:1765-1774

​

Kimura Y, Izumiya Y, Araki S, Yamamura S, Hanatani S, Onoue Y, Ishida T, Arima Y, Nakamura T, Yamamoto E, Senokuchi T, Yoshizawa T, Sata M, Kim-Mitsuyama S, Nakagata N, Bober E, Braun T, Kaikita K, Yamagata K, Tsujita K.

Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation.

Circ J2021 85: 2232-2240

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Arima Y, Nakagawa Y, Takeo T, Ishida T, Yamada T, Hino S, Nakao M, Hanada S, Umemoto T, Suda T, Sakuma T, Yamamoto T, Watanabe T, Nagaoka K, Tanaka Y, Kawamura YK, Tonami K , Kurihara H, Sato Y, Yamagata K, Nakamura T, Araki S, Yamamoto E, Izumiya Y, Sakamoto K, Kaikita K, Matsushita K, Nishiyama K, Nakagata N, Tsujita K.

Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation. 

Nat Metab.20213:196-210

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Morita Y, Senokuchi T, Yamada S, Wada T, Furusho T, Matsumura T, Ishii N, Nishida S, Nishida S, Motoshima H, Komohara Y, Yamagata K, Araki E.

Impact of tissue macrophage proliferation on peripheral and systemic insulin resistance in obese mice with diabetes.

BMJ Open Diabetes Res Care2020 Oct;8(1):e001578. 

​

2020

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Sato Y, Rahman MM, Haneda M, Tsuyama T, Mizumoto T, Yoshizawa T, Kitamura T, Gonzalez FJ, Yamamura KI, Yamagata K.

HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1.

Biochim Biophys Acta Mol Basis Dis.2020 Jul 22;1866(11):165898.

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Kariba Y, Yoshizawa T, Sato Y, Tsuyama T, Araki E, Yamagata K.

Brown adipocyte-derived exosomal miR-132-3p suppresses hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes.

Biochem Biophys Res Commun.2020 In press.

​

Yamamura S, Izumiya Y, Araki S, Nakamura T, Kimura Y, Hanatani S, Yamada T, Ishida T, Yamamoto M, Onoue Y, Arima Y, Yamamoto E, Sunagawa Y, Yoshizawa T, Nakagata N, Bober E, Braun T , Sakamoto K, Kaikita K, Morimoto T, Yamagata K, Tsujita K.

Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4.

Hypertension 75(1):98-108, 2020

​

2019

Sobuz SU, Sato Y, Yoshizawa T, Karim F, Ono K, Sawa T, Miyamoto Y, Oka M, Yamagata K
SIRT7 regulates the nuclear export of NF-κB p65 by deacetylating Ran.
Biochim Biophys Acta Mol Cell Res. 1866(9):1355-1367, 2019

​

2018

Fukuda M, Yoshizawa T, Karim MF, Sobuz SU, Korogi W, Kobayasi D, Okanishi H, Tasaki M, Ono K, Sawa T, Sato Y, Chirifu M, Masuda T, Nakamura T, Tanoue H, Nakashima K, Kobashigawa Y ,Morioka H,Bober E,Ohtsuki S,Yamagata Y,Ando Y,Oike Y,Araki N,Takeda S,Mizuta H,Yamagata K
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
Nat Commun. 9(1):2833, 2018

Miyasato Y, Yoshizawa T, Sato Y, Nakagawa T, Miyasato Y, Kakizoe Y, Kuwabara T, Adachi M, Ianni A, Braun T, Komohara Y, Mukoyama M, Yamagata K
Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response.
Scientific Reports 8:5927, 2018

Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishi N, Fukuda K, Murakami S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Yamagata K, Takeya M, Araki E
Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis and insulin resistance.
Arterioscler Thromb Vasc Biol.38:994-1006, 2018

Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K
SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.
Biochem Biophys Res Commun. 496:891-97, 2018

Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, Endo M, Zhu S, Fan H, Horiguchi H, Morinaga J, Terada K, Yoshizawa T, Yamagata K, Oike Y
Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice.
J Biol Chem. 293:1596-1609,2018

Islam MS, Wei FY, Ohta K, Shigematsu N, Fukuda T, Tomizawa K, Yoshizawa T, Yamagata K
Sirtuin 7 is involved in the consolidation of fear memory in mice.
Biochem Biophys Res Commun. 495:261-66, 2018

Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K , Fukuda T, Mizuta H, Oike Y
Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.
Osteoarthr Cartilage 26: 108-117, 2018

Yamagata K, Yoshizawa T
Transcriptional regulation of metabolism by SIRT1 and SIRT7.
Int Rev Cell Mol Biol.335:143-166, 2018

​

2017

Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K
Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Biochem Biophys Res Commun. 490:423-28, 2017

Sato Y, Tsuyama T, Sato C, Karim MF, Yoshizawa T, Inoue M, Yamagata K
Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase.
J Biol Chem. 292:8716-28, 2017

Nomiyama H, Osada N, Takahashi I, Terao K, Yamagata K, Yoshie O
Translational repression of a splice variant of cynomolgus macaque CKCL1L by its C-terminal sequence.
J Interferon Cytokine Res.37:129-138, 2017

​

2016

Jono H, Su Y, Obayashi K, Tanaka Y, Ishiguro A, Nishimura H, Shinriki S, Ueda M, Ikeda K, Yamagata K, Ichihara K, Ando Y
Sources of variation of transthyretin in healthy subjects in East and Southeast Asia: Clinical and experimental evidence for the effect of alcohol on transthyretin metabolism.
Clin Chim Acta.458:5-11, 2016

​

2015

Araki S, Izumiya Y, Rokutanda T, Ianni A, Hanatani S, Kimura Y, Onoue Y, Senokuchi T, Yoshizawa T, Yasuda O, Koitabashi N, Kurabayashi M, Braun T, Bober E, Yamagata K, Ogawa H
Sirt7 contributes to myocardial tissue repair by maintaining TGF-b signaling pathway.
Circulation 132:1081-1093, 2015

Yamagata K, Karim MF, Sato Y, Yoshizawa T
Role of SIRT7 in hepatic lipid metabolism.
Diabetol Int. 6:193-196, 2015

Yoshikawa Y, Yoshizawa T, Domae E, Hieda Y, Takeyama A, Hirota S, Kawamoto A, Goda S, Tamura I, Kamada A, Komasa Y, Morita S, Yamagata K, Ikeo T
RNA interference-mediated knockdown of Smad1 inhibits receptor activator of nuclear factor kB ligand expression induced by BMP-2 in primary osteoblasts.
Arch Oral Biol 60:1319-1326, 2015

Kurokawa H, Ito H, Inoue M, Tabata K, Sato Y, Yamagata K, Kizaka-Kondoh S, Kadonosono T, Yano S, Inoue M, Kamachi T
High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime.
Scientific Reports 5:10657, 2015

Hayashi H, Sato Y, Li Z, Yamamura KI, Yoshizawa T, Yamagata K
Roles of hepatic glucokinase in intertissue metabolic communication: examination of novel liver-specific glucokinase knockout mice.
Biochem Biophys Res Commun. 460:727-32, 2015

​

2014

Sato Y, Inoue M, Yoshizawa T, Yamagata K.
Moderate hypoxia induces b-cell dysfunction with HIF-1–independent gene expression changes.
PLOS ONE 9:e114868, 2014

Ohki T, Utsu Y, Morita S, Karim MF, Sato Y, Yoshizawa T, Yamamura K, Yamada K, Kasayama S, Yamagata K.
Low serum level of high-sensitivity C-reactive protein in a Japanese patient with maturity-onset diabetes of the young type 3 (MODY3)
J Diabetes Invest. 5:513-516, 2014

Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E ,Takaaki Akaike T, Braun T, Oike Y, Bober E, Yamagata K
SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway.
Cell Metabolism 19:712-721,2014

Yamagata K
Roles of HNF1α and HNF4α in pancreatic β-cells: lessons from a monogenic form of diabetes (MODY).
Vitam Horm. 95:407-423,2014

​

2013

Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, Sekine K, Sato T, Kawano H, Aihara K, Nakamichi Y, Watanabe T, Shindo M, Inoue K, Inoue E, Tsuji N, Hoshino M, Karsenty G, Metzger D, Chambon P, Kato S, Imai Y
Vitamin D receptor in osteoblasts is a negative regulator of bone mass control.
Endocrinology154: 1008-1020, 2013

Kozawa J, Okita K, Iwahashi H, Yamagata K, Imagawa A, Shimomura I
Early postprandial glucagon surge affects postprandial glucose levels in obese and non-obese patients with type 2 diabetes.
Endocr J.60(6):813-818, 2013

Karim MF, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, Akaike T, Yamagata K
Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a)
Biochem Biophys Res Commun441:157-163, 2013

Kazuya Yamagata
Types of fatty acids and fatty acid synthesis pathways
Endocrinology/Diabetes/Metabolism 36:467-470, 2013

​

year 2012

Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, Yamagata K
Anks4b, a novel target of HNF4α interacts with GRP78 and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
J. Biol Chem.287:23236-45, 2012

Ohki T, Sato Y, Yoshizawa T, Yamamura KI, Yamada K, Yamagata K
Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells.
Biochem Biophys Res Commun425(3):619-24, 2012

Su Y, Misumi Y, Ueda M, Shono M, Tasaki M, Jono H, Obayashi K, Senokuchi T, Yamagata K, Ando Y
The occurrence of islet amyloid polypeptide amyloidosis in Japanese subjects.
Pancreas41: 971-973, 2012

Su Y, Jono H, Misumi Y, Senokuchi T, Guo J, Ueda M, Shinriki S, Tasaki M, Shono M, Obayashi K, Yamagata K, Araki E, Ando Y
Novel function of transthyretin in pancreatic cells.
FEBS Letters.586: 4215-4222, 2012

Uncle Sato, Kazuya Yamagata, Masahiro Inoue
hypoxia and diabetes, cancer
Endocrinology/Diabetes/Metabolism 35: 264-269, 2012

Uncle Sato, Kazuya Yamagata
Hypoxia response and abnormal glucose metabolism in pancreatic β-cells
Experimental Medicine Special Edition Homeostatic control and disease by reactive oxygen and gaseous molecules Supervisor: Masayuki Yamamoto, Yodosha: 146-152, 2012

Kazuya Yamagata
MODY
Manual for Childhood and Adolescent Diabetes Edited by Hiroshi Ikegami, Nakayama Shoten: 81-87, 2012

Kazuya Yamagata
Transcription factors involved in the differentiation of pancreatic β-cells and lifestyle-related diseases -Transcription factors and diabetes-
Supplementary Volume: History of Medicine Energy Metabolism Transcription Factor Networks and Lifestyle Diseases Edited by Hitoshi Shimano
Ishiyaku Publishing Co., Ltd.: 60-64, 2012

Kazuya Yamagata
Basic Knowledge for Tailor-Made Medicine: Monogenic Diabetes (MODY)
Monthly Diabetes 6: 112-116, 2012

​

2011

Iwahashi H, Akita E, Tokunaga A, Okita K, Horikawa Y, Imagawa A, Funahashi T, Shimomura I, Yamagata K
Clinical features of Japanese type 2 diabetics with insulinogenic index in normal range after treatment of glucotoxicity.
Diabetol Int.2. 208-213, 2011

Wei FY, Suzuki T, Watanabe S, Kimura S, Kaitsuka T, Fujimura A, Matsui H, Atta M, Michiue H, Fontecave M, Yamagata K, Suzuki T, Tomizawa K
Deficit of Lys-tRNA Modification by Cdkal1 Causes the Development of Type 2 Diabetes in Mice.
J. Clin. Invest.121: 3598-3608, 2011

Yano M, Watanabe K, Yamamoto T, Ikeda K, Senokuchi T, Lu M, Kadomatsu T, Tsukano H, Ikawa M, Okabe M, Yamaoka S, Okazaki T, Umehara H, Gotoh T, Song WJ, Node K, Taguchi R , Yamagata K, Oike Y
Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1 null mice.
J Biol Chem.286: 3992-4002, 2011

Sato Y, Endo H, Okuyama H, Takeda T, Iwahashi H, Imagawa A, Yamagata K, Shimomura I, Inoue M
Cellular hypoxia of pancreatic β-cells due to high levels of oxygen consumption for insulin secretion in vitro.
J Biol. Chem.286: 12524-12532, 2011

Yamagata K, Senokuchi T, Lu M, Takemoto M, Karim MF, Go C, Sato Y, Hatta M, Yoshizawa T, Araki E, Miyazaki J, Song WJ
Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 β-cell line.
Biochem Biophys Res Commun.407: 620-625, 2011

Kazuya Yamagata
Transcription factors involved in the differentiation of pancreatic β-cells and lifestyle-related diseases -Transcription factors and diabetes-
Journal of Medicine 237 (6):672-676, 2011

​

2010

Kozawa J, Okita K, Imagawa A, Iwahashi H, Holst JJ, Yamagata K, Shimomura I
Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes.
Biochem Biophys Res Commun.393: 410-413, 2010

Higuchi Y, Shiraki N, Yamane K, Qin Z, Mochitate K, Araki K, Senokuchi T, Yamagata K, Hara M, Kume K, Kume S
Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages.
J Cell Sci.123: 2733-2742, 2010

Kazuya Yamagata
MODY gene abnormality and diabetes
Diabetes Diagnostic Criteria 2010-Clinical Application and Practice- Diabetes Lecture 1:447-452, 2010

Kazuya Yamagata
HNF family and adiposcience
Adiposcience "Nuclear receptors and adiposcience" 7: 162-167, 2010

Kazuya Yamagata
Nuclear receptors and diabetes
Hormones and clinical "Nuclear receptors and endocrine diseases UPDATE" 58: 137-141, 2010

Kazuya Yamagata
Regulation of β-cell function by transcription factors
Diabetes Navigator 2nd edition pp36-37, edited by Ko Kadowaki, Medical Review 2010

Kazuya Yamagata
Diabetes genes for monogenic disease types
Journal of Medicine 232: 1173-1177, 2010

​

2009

Miyake K, Yang W, Hara K, Yasuda K, Horikawa Y, Osawa H, Furuta H, Ng M CY, Hirota Y, Mori H, Ido K, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamda Y, Seino Y, Maegawa H, Kashiwagi A, Wang Hy, Tanahashi T, Nakamura N, Takeda J, Maeda E, Yamamoto K, Tokunaga K, Ma RCW, So WY, Chan JCN, Kamatani N, Makino H, Nanjo K, Kadowaki T, Kasuga M
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on eleven genes with strong evidence of the association.
J Hum Genet. 54: 236-241, 2009

Okauchi Y, Nammo T, Iwahashi H, Kizu T, Hayashi I, Okita K, Yamagata K, Uno S, Katsube F, Matsuhisa M, Kato K, Aozasa K, Kim T, Osuga K, Nakamori S, Tamaki Y, Funahashi T , Miyagawa J, Shimomura I
Glucagonoma diagnosed by arterial stimulation and venous sampling (ASVS).
48: 1025-1030, 2009

Saisho K, Fukuhara A, Yasuda T, Sato Y, Fukui K, Iwahashi H, Imagawa A, Hatta M, Shimomura I, Yamagata K
Glucose enhances collectrin protein expression in insulin-producing MIN6 β cells.
Biochem. Biophys. Res. Commun. 389: 133-137, 2009

Kazuya Yamagata
diabetes and genes
Advances in Diabetology 2009 Vol. 43 pp73-76, Edited by the Japan Diabetes Society Diagnosis and Treatment 2009

Kazuya Yamagata
diabetic ketoacidosis
Today's Treatment Guidelines 2009 Igaku Shoin pp541-542, 2009

Kazuya Yamagata
Nucleus: Nuclear transcription factors and diabetes
Diabetes Frontier Medical Review 1(20):109-113,2009

​

2008

Miyake K, Horikawa Y, Hara K, Yasuda K, Osawa H, Furuta H, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K , Tokunaga K, Takeda J, Makino H, Nanjo K, Kadowaki T, Kasuga M
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
J Hum Genet. 53: 174-180, 2008

Nagai R, Fujiwara Y, Mera K, Yamagata K, Sakashita N, Takeya M
Immunochemical detection of Nε-carboxyethyl lysine using a specific antibody.
J Immunol Methods 332: 112-120, 2008

Tokunaga A, Miura A, Okauchi Y, Segawa K, Fukuhara A, Okita K, Takahashi M, Funahashi T, Miyagawa JI, Shimomura I, Yamagata K
The -1535 promoter variant of the visfatin gene is associated with serum triglyceride and HDL-cholesterol levels in Japanese subjects.
Endocr J. 55: 205-212, 2008

Horikawa Y, Miyake K, Yasuda K, Enya M, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J , Kasuga M
Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.
J Clin Endocrinol Metab.93: 889-893, 2008

Okauchi Y, Iwahashi H, Okita K, Yuan M, Matsuda M, Tanaka T, Miyagawa J, Funahashi T, Horikawa Y, Shimomura I, Yamagata K
PGC-1α Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men.
Endocr J. 55: 991-997, 2008

Tamba S, Nishizawa H, Funahashi T, Okauchi Y, Ogawa T, Noguchi M, Fujita K, Ryo M, Kihara S, Iwahashi H, Yamagata K, Nakamura T, Shimomura I, Matsuzawa Y
Relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men.
Intern Med. 47:1175-1180, 2008

Tokunaga A, Horikawa Y, Fukuda-Akita E, Okita K, Iwahashi H, Shimomura I, Takeda J, Yamagata K
A common P2 promoter polymorphism of the hepatocyte nuclear factor-4a gene is associated with insulin secretion in non-obese Japanese with type 2 diabetes.
Endocr J. 55: 999-1004, 2008

Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N , Iwamoto Y, Yamda Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, So WY, Chan JC, Lyssenko Y, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.
Nat Genet. 40: 1092-1097, 2008

Enya M, Horikawa Y, Kuroda E, Yonemura K, Tonooka N, Tomura H, Oda N, Yokoi N, Yamagata K, Shihara N, Iizuka K, Saibara T, Seino S, Takeda J
Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients.
Hum Mutat. 29: E271-277, 2008

Yasuhara A, Wada J, Malakauskas SM, Zhang Y, Eguchi J, Nakatsuka A, Murakami K, Kanzaki M, Teshigawara S, Yamagata K, Le TH, Makino H
Collectrin is involved in the development of salt-sensitive hypertension by facilitating the membrane trafficking of apical membrane proteins via interaction with soluble N-ethylmaleiamide-sensitive factor attachment protein receptor complex.
Circulation 118: 2146-2155, 2008

Fukuda-Akita E, Okita K, Okauchi Y, Ryo M, Nakamura T, Funahashi T, Iwahashi H, Shimomura I, Miyagawa J, Yamagata K
Impaired early insulin secretion in Japanese type 2 diabetes with metabolic syndrome.
Diabetes Res Clin Pract 79: 482-489, 2008

Nammo T, Yamagata K, Tanaka T, Kodama T, Sladek FM, Fukui K, Katsube F, Sato Y, Miyagawa J, Shimomura I
Expression of HNF-4α (MODY1), HNF-1α (MODY5), and HNF-1α (MODY3) proteins in the developing mouse pancreas.
Gene Expr Patterns. 8: 96-106, 2008

Kazuya Yamagata
Diabetes-associated transcription factors
Transcriptional Regulation and Epigenetics -Toward Genome Decoding- P189-195 Nanzando 2008

Kazuya Yamagata
Impaired insulin synthesis and secretion due to abnormal transcription factors
Advances in Diabetology 2008 Vol.42 p10-13, Edited by the Japan Diabetes Society Diagnosis and Treatment 2008

Kazuya Yamagata
Collectrin
－Diabetology in the New Era－ Nihon Rinshin Vol.66 Supplement 9,673-677,2008

Kazuya Yamagata
Significance of nuclear receptors in glucose metabolism
Molecular Cardiovascular Disease Advanced Medicine 33(255)-37(259), 2008

Kazuya Yamagata
Recent Findings on the MODY Gene -Including Choice of Treatment-
DIABETES JOURNAL Diabetes and Metabolism 36(2): 1-6, 2008

Kazuya Yamagata
Nuclear receptors and diabetes
Genomic Medicine Medical Review 8(1): 49-53, 2008

Kazuya Yamagata
Diabetes due to a single gene abnormality Diabetology in the age of MODY gene progression (1) - Advances in research on etiology, diagnosis and treatment -
Nihon Rinshin Vol.66 Supplement No.3, p514-520, 2008

Kazuya Yamagata
Transcription factors involved in glucose metabolism and pancreatic β-cell dysfunction in type 2 diabetes
Advances in pancreatic β-cell research in type 2 diabetes Edited by Yasuo Terauchi p59-66, Diagnosis and Treatment 2008

​

2007

Uno S, Imagawa A, Okita K, Sayama K, Moriwaki M, Iwahashi H, Yamagata K, Tamura S, Matsuzawa Y, Hanafusa T, Miyagawa J, Shimomura I
Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumor necrosis factor-alpha in patients with recent-onset type 1 diabetes.
Diabetologia. 50: 596-601, 2007

Zhang Y, Wada J, Yasuhara A, Iseda I, Eguchi J, Fukui K, Yang Q, Yamagata K, Hiesberger T, Igarashi P, Zhang H, Wang H, Akagi S, Kanwar YS, Makino H
The Role for HNF-1β-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells.
PLoS ONE.2: e414, 2007.

Okauchi Y, Nishizawa H, Funahashi T, Ogawa T, Noguchi M, Ryo M, Kihara S, Iwahashi H, Yamagata K, Nakamura T, Shimomura I, Matsuzawa Y
Reduction of visceral fat is associated with decrease in the number of metabolic risk factors in Japanese men.
Diabetes Care. 30: 2392-2394, 2007

Zhang J, Tokui Y, Yamagata K, Kozawa J, Sayama K, Iwahashi H, Okita K, Miuchi M, Konya H, Hamaguchi T, Namba M, Shimomura I, Miyagawa JI
Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes.
Diabetologia 50: 1900-1909, 2007

Yamagata K, Nammo T, Sato Y, Saisho K, Shoda H, Fukui K
The HNF-1α-SNARE connection. Diabetes Obes Metab.
Suppl 2: 40-45, 2007

Kazuya Yamagata
The role of collectrin in exocytosis of insulin
Endocrinology and Diabetes 25(3): 229-232, 2007

Hiromi Iwahashi, Kazuya Yamagata
insulin secretagogue
New Developments in Diabetes-Related Injectable Drugs (Insulin, GLP-1, Glucagon) pp79-82 Edited by Mitsuyoshi Namba

Kazuya Yamagata
MODY overview and HNF disorders
Diabetology Basics and clinical pp364-367 Edited by Takashi Kadowaki, Shun Ishibashi, Hiroshi Sakura, Kazuyuki Tobe, Mitsuhiko Noda Nishimura Shoten 2007

Kazuya Yamagata
Regulation of pancreatic β-cell function by transcription factors
Diabetology Basics and clinical pp31-33 Edited by Takashi Kadowaki, Shun Ishibashi, Hiroshi Sakura, Kazuyuki Tobe, Mitsuhiko Noda Nishimura Shoten 2007

Kazuya Yamagata
Apparatus of insulin secretion The forefront of diabetes research in the era of metabolic syndrome
Journal of Medicine 220(13): 1134-1137, 2007

Kazuya Yamagata
Monogenetic disease and genome -Juvenile diabetes MODY-
Genomic Medicine 7(2): 69-74, 2007

Kazuya Yamagata
Drug therapy for type 2 diabetes: drugs that match the condition
Joslyn Diabetes Desk Book (translation) Supervised translation by Yuji Matsuzawa

Kazuya Yamagata
diabetes-causing gene
Diabetes medical treatment Q&A answering questions in the field pp380-381 Edited by Yasuo Terauchi Chugai Igakusha 2007

Kazuya Yamagata
Regulation of β-cell function by novel HNF-1 target gene collectrin
Diabetology 2007 pp69-74 Edited by: Yoshitomo Oka, Yukio Tanizawa Diagnosis and Treatment 2007

Kazuya Yamagata, Kenji Fukui
Collectrin and insulin secretion
Advances in Molecular Diabetology 2007 pp2-7 Edited by Masato Kasuga, Susumu Seino, Yoshihito Atsumi, Takashi Kadowaki Kinbara Publishing 2007

Kazuya Yamagata
Transcription factor HNF and collectrin
Advances in Diabetology 2007 pp7-10 Edited by Japan Diabetes Society Diagnosis and Treatment 2007

Kazuya Yamagata
Collectrin
Endocrinology and Diabetes 24(1): 76-79, 2007

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2006

Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I
Hepatocyte nuclear factor-4α is essential for glucose-stimulated insulin secretion by pancreatic β-cells.
J Biol Chem. 281: 5246-5257, 2006

Tokui Y, Kozawa J, Yamagata K, Zhang J, Ohmoto H, Tochino Y, Okita K, Iwahashi H, Namba M, Shimomura I, Miyagawa J
Neogenesis and proliferation of beta-cells induced by human betacellulin gene transduction via retrograde pancreatic duct injection of an adenovirus vector.
Biochem Biophys Res Commun. 350: 987-993, 2006

Kazuya Yamagata, Kenji Fukui: Collectrin
Inspection and Technology 34 (13): 1537-1538, 2006

Kazuya Yamagata, Kenji Fukui: Insulin secretion mechanism by collectrin
Diabetes Journal 34 (4): 163-164, 2006

Kazuya Yamagata
Transcription factor HNF and diabetes
Advances in Diabetology 2006 pp143-148 Edited by Japan Diabetes Society Diagnosis and Treatment 2006

Kazuya Yamagata
Maturity-onset diabetes of the young (MODY)
Latest Diabetes Science -Basics and Clinical Practice- pp187-194 Edited by Seiichiro Tarui, Takashi Kadowaki, Toshiaki Hanafusa Asakura Shoten 2006

Kazuya Yamagata
MODY and transcription factors
Endocrinology and Diabetes 23(1): 101-107, 2006

Kazuya Yamagata
Transcription factor abnormality and diabetes
Pharma medica 24 (4): 47-52, 2006

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Year 2005

Ozawa K, Miyazaki M, Matsuhisa M, Takano K, Nakatani Y, Hatazaki M, Tamatani T, Yamagata K, Miyagawa J, Kitao Y, Hori O, Yamasaki Y, Ogawa S
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.
Diabetes 54: 657-663, 2005

Ihara A, Yamagata K, Nammo T, Miura A, Ming Y, Tanaka T, Sladek FM, Matsuzawa Y, Miyagawa J, Shimomura I
Functional characterization of the HNF4 isoform (HNF4 8) expressed in pancreatic β-cells.
Biochem Biophys Res Commun. 329: 984-990, 2005

Kozawa J, Tokui Y, Moriwaki M, Li M, Ohmoto H, Yuan M, Zhang J, Iwahashi H, Imagawa A, Yamagata K, Tochino Y, Shimomura I, Higashiyama S, Miyagawa J
Regenerative and therapeutic effects of heparin-binding epidermal growth factor-like growth factor on diabetes by gene transduction via retrograde pancreatic duct injection of adnovirus vector.
Pancreas 31: 32-42, 2005

Sayama K, Imagawa A, Okita K, Uno S, Moriwaki M, Kozawa J, Iwahashi H, Yamagata K, Tamura S, Matsuzawa Y, Hanafusa T, Miyagawa J, Shimomura I
Pancreatic beta and alpha cells are both decreased in patients with fulminant type 1 diabetes: a morphometrical assessment.
Diabetologia 48: 1560-1564, 2005

Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H , Shimomura I, Miyagawa J, Wollheim CB, Yamagata K
The HNF-1 target Collectrin controls insulin exocytosis by SNARE complex formation.
2: 373-384, 2005

Shinsuke Nakata, Hiromi Iwahashi, Jungo Teramae, Hiroyuki Konya, Ming Yuan, Kohei Okita, Akihisa Imagawa, Tomoya Hamaguchi, Kazuya Yamagata, Iichiro Shimomura, Junichiro Miyagawa, Mitsuyoshi Namba, Toshiaki Hanafusa
Relationship between blood glucose improvement effect and endogenous insulin secretory ability by switching from rapid-acting to ultra-rapid-acting insulin preparations
Diabetes, Vol. 48, No. 10, 733-738 Glossary of Diabetology 2nd Edition (Glossary: Kazuya Yamagata) Edited by the Japan Diabetes Society, Bunkodo 2005

Kazuya Yamagata
MODY gene
Diabetes Frontier 16 (5): 561-566, 2005

Kazuya Yamagata
MODY (HNF family)
Diabetes and Genes (Diabetes Current Library) pp22-27 Edited by Yukio Horikawa, Kazumoto Yasuda Bunkodo 2005

Kazuya Yamagata
Diabetes prone disease susceptibility polymorphism
HNF-1α gene G319S polymorphism
Glucose intolerance -The latest information on basic and clinical research- Nihon Rinshin Vol.63 Supplement 2: 171-175, 2005

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2004

Shimamoto Y, Ishida J, Yamagata K, Saito T, Kato H, Matsuoka T, Hirota K, Daitoku H, Nangaku M, Yamagata K, Fujii H, Takeda J, Fukamizu A
Inhibitory effect of small heterodimer partner on hepatocyte nuclear factor 4 mediates bile acid-induced repression of human angiotensinogen gene.
J. Biol. Chem. 279: 7770-7776, 2004

Tomimoto S, Hashimoto H, Shintani N, Yamamoto K, Kawabata Y, Hamagami K, Yamagata K, Miyagawa J, Baba A
Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice.
J. Pharmacol. Exp. Ther. 309: 796-803, 2004

Yukiyoshi Okauchi, Takao Minami, Hiromi Iwahashi, Mayumi Tsubakio, Atsushi Yoshikawa, Isao Hayashi, Kohei Okita, Ken Kato, Munehide Matsuhisa, Yoshimitsu Yamazaki, Kazuya Yamagata, Toru Funabashi, Junichiro Miyagawa, Iichiro Shimomura
A case of diabetes mellitus with hemochromatosis in which insulin secretion ability and insulin resistance index could be tracked during the course
Diabetes Journal 32(3):90-94,2004

Kazuya Yamagata: Diabetes due to abnormal transcription factors: HNF diabetes
Journal of Medicine 211 (2): 163-166, 2004

Kazuya Yamagata: HNF gene family and diabetes
Diabetes 47(7): 504-507, 2004

Kazuya Yamagata
HNF-1 diabetes mellitus (MODY3)
Learning from 100 cases of diabetes Edited by Ryuzo Kawamori and Yoshimitsu Yamazaki Nagai Shoten 2004

Kazuya Yamagata
MODY gene: HNF family
History of Medicine Diabetes and Metabolic Syndrome-state of arts 2004-2006 Edited by Takashi Kadowaki Ishiyaku Shuppan 2004

Kazuya Yamagata
HNFMore
Diabetes Library "Insulin Secretion" pp133-137 Edited by Yoshitomo Oka Bunkodo 2004

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2003

Zhu Q, Yamagata K, Miura A, Shihara N, Horikawa Y, Takeda J, Miyagawa J, Matsuzawa Y
T130I mutation in HNF-4 gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects.
Diabetologia 46: 567-573, 2003

Yamamoto K, Hashimoto H, Tomimoto S, Shintani N, Miyazaki J, Tashiro F, Aihara H, Nammo T, Li M, Yamagata K, Miyagawa J, Matsuzawa Y, Kawabata Y, Fukuyama Y, Koga K, Mori W, Tanaka K , Matsuda T, Baba A
Overexpression of PACAP in transgenic mouse pancreatic cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes.
Diabetes 52: 1155-1162, 2003

Yamagata K: Regulation of pancreatic-cell function by the HNF transcription network
Lessons from maturity-onset diabetes of the young (MODY).
Endocr J. 50: 491-499, 2003

Iwahashi H, Funahashi T, Kurokawa N, Sayama K, Fukuda E, Okita K, Imagawa A, Yamagata K, Shimomura I, Miyagawa J, Mtsuzawa Y
Plasma adiponectin levels in women with anorexia nervosa. Horm.
Metab. Res. 35: 537-540, 2003

Kishida K, Moriwaki M, Miyagawa J, Okita K, Kondo T, Itoh K, Umemura S, Kozawa J, Iwahashi H, Yoshizumi T, Imagawa A, Yamagata K, Maruyama T, Toyoshima T, Kurokawa K, Funahashi T, Matsuzawa Y
Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing' syndrome.
Internal Med 42: 9966-1005, 2003

Li M, Miyagawa J, Moriwaki M, Yuan M, Yang Q, Kozawa J, Yamamoto K, Imagawa A, Iwahashi H, Tochino Y, Yamagata K, Matsuzawa Y
Analysis of expression profiles of islet-associated transcription and growth factors during β-cell neogenesis from duct cells in partially duct-ligated mice.
Pancreas 27: 345-355, 2003

Hiromi Iwahashi, Satoko Marukawa, Yumi Matsumoto, Akihisa Imagawa, Kenji Fukui, Koichi Sayama, Makoto Moriwaki, Kohei Okita, Koji Yamamoto, Kazuya Yamagata, Yoshimitsu Yamazaki, Toru Funabashi, Junichiro Miyagawa, Yuji Matsuzawa
Efficacy of pioglitazone on insulin resistance in myotonic dystrophy--a study in three non-obese patients
Diabetes Journal 31:92-96, 2003

Kazuya Yamagata
MODY
Internal Medicine Keywords 2003 (June Enlarged Issue) Internal Medicine 91 (6): 1413-1414, 2003

Kazuya Yamagata
``HNF gene family'' to search for diabetes genes
Molecular Medicine 40 (1): 96-101, 2003

​

2002

Yoshiuchi I, Yamagata K, Zhu Q, Tamada I, Takahashi Y, Onigata K, Takeda J, Miyagawa J, Matsuzawa J
Identification of a gain-of-function mutation in the HNF-1β gene in a Japanese family with MODY.
Diabetologia 45: 153-154, 2002

Yamagata K, Nammo T, Moriwaki M, Ihara A, Iizuka K, Yang Q, Satoh T, Li M, Uenaka R, Okita K, Iwahashi H, Zhu Q, Cao Y, Imagawa A, Tochino Y, Hanafusa T, Miyagawa J , Matsuzawa Y
Overexpression of dominant-negative mutant HNF-1α in pancreatic β-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced β-cell proliferation and diabetes.
Diabetes 51: 114-123, 2002

Nishizawa H, Yamagata K, Shimomura I, Takahashi M, Kuriyama H, Kishida K, Hotta K, Nagaretani H, Maeda N, Matsuda M, Kihara S, Nakamura T, Nishigori H, Tomura H, Moore DD, Takeda J, Funahashi T , Matsuzawa Y
Small heterodimer partner, an orphan nuclear receptor, augments PPAR transactivation.
J. Biol. Chem. 277: 1586-1592, 2002

Iwahashi H, Yamagata K, Yoshiuchi I, Terasaki J, Yang Q, Fukui K, Ihara A, Zhu Q, Asakura T, Cao Y, Imagawa A, Namba M, Hanafusa T, Miyagawa J, Matsuzawa Y
Thyroid hormone receptor interacting protein (Trip3) is a novel coactivator of hepatocyte nuclear factor-4α (HNF-4α).
Diabetes 51: 910-914, 2002

Yang Q, Yamagata K, Fukui K, Cao Yang, Nammo T, Iwahashi H, Wang H, Matsumura I, Hanafusa T, Bucala R, Wollheim CB, Miyagawa J, Matsuzawa Y
Hepatocyte nuclear factor-1α modulates pancreatic β-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells.
Diabetes 51: 1785-1792, 2002

Triggs-Raine BL, Kirkpatrick RD, Kelly SL, Norquay LD, Cattini PA, Yamagata K, Hanley AJ, Zinman B, Harris SB, Barrett PH, Hegele RA
HNF-1α G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community.
Proc Natl Acad Sci USA 99: 4614-4619, 2002

Nammo T, Yamagata K, Hamaoka R, Zhu Q, Akiyama TE, Gonzalez FJ, Miyagawa J, Matsuzawa Y
Expression profile of MODY3/HNF-1α protein in the developing mouse pancreas.
Diabetologia 45: 1142-1153, 2002

Imagawa A, Funahashi T, Nakamura T, Moriwaki M, Tanaka S, Nishizawa H, Sayama K, Uno S, Iwahashi H, Yamagata K, Miyagawa J, Matsuzawa Y
Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes.
Diabetes Care 25: 1665-1666, 2002

Ming LI, Miyagawa J, Yamamoto K, Moriwaki M, Imagawa A, Iwahashi H, Yamagata K, Tochino Y, Hanafusa T, Matsuzawa Y
β cell neogenesis from ducts and phenotypic conversion of residual islet cells in the adult pancreas of glucose intolerant mice induced selective alloxan perfusion.
Endocrine J. 49: 561-572, 2002

Hara K, Noda M, Waki H, Tobe K, Yamauchi T, Kadowaki H, Satou H, Tsukamoto K, Nagamatsu S, Yamagata K, Matsuzawa Y, Akanuma Y, Kimura S, Kadowaki T
Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4α gene.
Internal Med 41: 848-852, 2002

Kazuya Yamagata, Yuji Matsuzawa: MODY and Nuclear Receptors
Hormone and Clinical Vol.51 Spring Special Issue "Progress in Steroid Hormone Research 2002", 48-51, 2002

Kenji Fukui, Akihisa Imagawa, Hiromi Iwahashi, Hiroshi Kashine, Shin Moriwaki, Takao Minamishige, Susumu Misugi, Kenji Sekiguchi, Kazuya Yamagata, Junichiro Miyagawa, Yuji Matsuzawa
A case of diabetes with acute pancreatitis and pancreatic biopsy showing histology similar to non-autoimmune fulminant type 1 diabetes mellitus
Diabetes 45(10): 759-765, 2002

Ming Li, Koji Yamamoto, Shin Moriwaki, Ming Yuan, Takao Nanmo, Akihisa Imagawa, Hiromi Iwahashi, Kazuya Yamagata, Yoshihiro Tono, Junichiro Miyagawa, Yuji Matsuzawa
Neogenesis from duct cells to cells in partially ligated duct mice
Diabetes Frontier 13(5): 678, 2002

Kazuya Yamagata
Regulation of insulin secretory ability and sensitivity by nuclear receptor network
Endocrinology and Diabetes 15 (6): 590-593, 2002

Kazuya Yamagata
《New Perspective on Diabetes Pathogenesis》Diabetes as a Transcription Factor Disease
Internal Medicine 91(1): 59-62, 2003

Kazuya Yamagata
Pancreatic Cell Transcription Factors 200 Words to Know - For Understanding Modern Medicine
History of Medicine 200(13) 1182-1183, 2002 Iyaku Shuppan Co., Ltd.

Kazuya Yamagata
Regulation of β-cell function by transcription factors
Diabetes Navigator pp24-25 Edited by Takashi Kadowaki Medical Review 2002

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2001

Nishigori H, Tomura H, Tonooka N, Kanamori M, Yamada S, Sho K, Inoue I, Kikuchi N, Onigata K, Kojima I, Kohama T, Yamagata K, Yang Q, Matsuzawa Y, Miki T, Seino S, Kim Mi -Y, Choi HS, Lee YW, Moore DD, Takeda J
Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese.
Proc. Natl. Acad. Sci. USA 98: 575-580, 2001

Zhu Q, Yamagata K, Tsukahara Y, Yang Q, Liu W, Hanafusa T, Miyagawa J, Matsuzawa Y
Mutation screening of the hepatocyte nuclear factor (HNF)-6 gene in Japanese subjects with diabetes mellitus.
Diabetes Res Clin Pract 52: 171-174, 2001

Imagawa A, Hanafusa T, Tamura S, Moriwaki M, Itoh N, Yamamoto K, Iwahashi H, Yamagata K, Waguri M, Nammo T, Uno S, Nakajima H, Namba M, Kawata S, Miyagawa J, Matsuzawa Y
Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes mellitus-Close correlation between serological markers and histological evidence of cellular autoimmunity-.
Diabetes 50: 1269-1273, 2001

Mori H, Ikegami H, Kawaguchi Y, Seino S, Yokoi N, Takeda J, Inoue I, Seino Y, Yasuda K, Hanafusa T, Yamagata K, Awata T, Kadowaki T, Hara K, Yamada N, Gotoda T, Iwasaki N , Iwamoto Y, Sanke T, Nanjo K, Oka Y, Matsutani A, Maeda E, Kasuga M
The Pro12 --Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.
Diabetes 50: 891-894, 2001

Yoshiuchi I, Yamagata K, Yoshimoto M, Zhu Q, Yang Q, Nammo T, Uenaka R, Kinoshita E, Hanafusa T, Miyagawa J, Matsuzawa Y
A non-functional HNF-1α mutation in Japanese subjects with familial type 1 diabetes.
Human Mutation 18: 345-351, 2001

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Before 2000

Yamada S, Zhu Q, Aihara Y, Onda H, Zhang Z, Yu L, Jin L, Si Y, Nishigori H, Tomura H, Inoue I, Morikawa A, Yamagata K, Hanafusa T, Matsuzawa Y, Takeda J
Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3β and mutation screening in Japanese subjects with MODY.
Diabetologia 43: 121-124, 2000

Yang Q, Yamagata K, Yamamoto K, Cao Y, Miyagawa J, Fukamizu A, Hanafusa T, Matsuzawa Y
R127-HNF-4α is a loss of function mutation but not a rare polymorphism and causes Type II diabetes in a Japanese family with MODY1.
Diabetologia 43: 520-524, 2000.

Zhu Q, Yamagata K, Yu L, Tomura H, Yamada S, Yang Q, Yoshiuchi I, Sumi S, Miyagawa J, Takeda J, Hanafusa T, Matsuzawa Y
Identification of missense mutations in the hepatocyte nuclear factor-3β gene in Japanese subjects with late-onset type 2 diabetes mellitus.
Diabetologia 43: 1197-1200, 2000

Takahashi M, Arita Y, Yamagata K, Matsukawa Y, Okutomi K, Horie M, Shimomura I, Hotta K, Kuriyama H, Kihara S, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y
Genomic structure and mutations in adipose-specific gene, adiponectin.
International Journal of Obesity 24: 861-868, 2000.

Yamamoto K, Miyagawa J, Waguri M, Sasada R, Igarashi K, Li M, Nammo T, Moriwaki M, Imagawa A, Yamagata K, Nakajima H, Namba M, Tochino Y, Hanafusa T, Matsuzawa Y
Recombinant human betacellulin promotes the neogenesis of β-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion.
Diabetes 49: 2021-2027, 2000

Kazuya Yamagata
Diabetes/Obesity
Vascular Medicine 1(2): 73-84, 2000

Kazuya Yamagata
Maturity-onset diabetes of the young (MODY)
Latest Medicine 2000

Kazuya Yamagata, Yuji Matsuzawa
Regulation of cell functions by transcription factors and their abnormalities
Journal of Medicine 192(5): 326-329, 2000

Kazuya Yamagata, Yuji Matsuzawa
HNF abnormalities and diabetes
Monthly Pharmaceutical Affairs 42(4): 1129-1133, 2000

Kazuya Yamagata, Toshiaki Hanafusa, Yuji Matsuzawa
diabetes and transcription factors
Modern Medicine 32(2):423-430, 2000

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1999

Yoshiuchi I, Yamagata K, Yang Q, Iwahashi H, Okita K, Yamamoto K, Oue T, Imagawa A, Hamaguchi T, Yamasaki T, Horikawa Y, Satoh T, Nakajima H, Miyazaki J, Higashiyama S, Miyagawa J, Namba M , Hanafusa T, Matsuzawa Y
Three new mutations in the hepatocyte nuclear factor-1α gene in Japanese subjects with diabetes mellitus: Clinical features and functional characterization.
Diabetologia 42: 621-626, 1999

Imagawa A, Hanafusa T, Itoh N, Waguri M, Yamamoto K, Miyagawa J, Moriwaki M, Yamagata K, Iwahashi H, Sada M, Tsuji T, Tamura S, Kawata S, Kuwajima M, Nakajima H, Namba M, Matsuzawa Y
In situ immunological abnormalities in islets paralleled further deterioration of glycemic control in recent-onset type 1 (insulin-dependent) diabetes mellitus patients.
Diabetologia 42: 574-578, 1999

Iwahashi H, Hanafusa T, Imagawa A, Tomita K, Moriwaki M, Yamamoto K, Waguri M, Yamagata K, Itoh N, Yoshiuchi I, Nanmo T, Nakajima H, Miyagawa J, Namba M, Matsuzawa Y
Emerging therapeutic strategies in autoimmune diabetes: aetiology, prediction, prevention and cure.
Emerging Therapeutic Targets 3: 177-193, 1999

Tomura H, Nishigori H, Sho K, Yamagata K, Inoue I, Takeda J
Loss-of-function and dominant-negative mechanisms associated with hepatocyte nuclear factor-1β mutations in familial type 2 diabetes mellitus.
J. Biol. Chem. 274: 12975-12978, 1999

Moriwaki M, Itoh N, Miyagawa J, Yamamoto K, Imagawa A, Yamagata K, Iwahashi H, Nakajima H, Namba M, Kuwajima M, Nagata S, Hanafusa T, Matsuzawa Y
Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type 1 diabetes mellitus.
Diabetologia 42: 1332-1340, 1999

Okita K, Yang Q, Yamagata K, Hangenfeldt KA, Miyagawa J, Kajimoto Y, Nakajima H, Namba M, Wollheim CB, Hanafusa T, Matsuzawa Y
Human insulin gene is a target of hepatocyte nuclear factor-1α (HNF-1α) and HNF-1α.
Biochem. Biophys. Res. Commun. 263: 566-569, 1999

Yang Q, Yamagata K, Yamamoto K, Miyagawa J, Takeda J, Iwasaki N, Iwahashi H, Yoshiuchi I, Namba M, Miyazaki J, Hanafusa T, Matsuzawa Y
Structure/function studies of hepatocyte nuclear factor-1α, a diabetes-associated transcription factor.
Biochem. Biophys. Res. Commun. 266: 196-202, 1999

Qin Yang, Kazuya Yamagata, Kohei Okita, Koji Yamamoto, Hiromi Iwahashi, Kazumasa Yoshiuchi, Koji Yamamoto, Mitsuyoshi Namba, Junichiro Miyagawa, Toshiaki Hanabusa, Yuji Matsuzawa
molecular diabetes
Molecular Diabetology 1999 vol10, p93-96, Molecular Diabetes Study Group, Ishiyaku Shuppan 1999

Kazuya Yamagata, Toshiaki Hanafusa, Yuji Matsuzawa
MODY classification and genetic abnormalities
Pediatric Internal Medicine 31(9):1282-1284, 1999

Kazuya Yamagata, Yuji Matsuzawa
Diabetes due to abnormalities in the MODY-HNF cascade
Journal of Medicine 187(7) 477-481, 1999

Naoto Ito, Kazuya Yamagata
Diabetes chronic complications-neuropathy-
Comprehensive Diagnosis of Internal Medicine p517-519 Edited by Seiichiro Tarui, Yuji Matsuzawa and Sumio Kawada Asakura Shoten 1999

Kazuya Yamagata, Yuji Matsuzawa
Genetic analysis of MODY and its pathogenesis
Advances in Diabetology' 99 Volume 33 p130-136 Edited by the Japan Diabetes Society Diagnosis and Treatment Publishing 1999

Kazuya Yamagata, Yuji Matsuzawa
Endogenous ligand for HNF-4
Endocrinology and Diabetes 9(2): 152-154, 1999

Kazuya Yamagata, Toshiaki Hanafusa, Yuji Matsuzawa
HNF aberrant diabetes mellitus
Cell Engineering 18(2): 254-258, 1999

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1998

Iwahashi H, Itoh N, Yamagata K, Imagawa A, Nakajima H, Tomita K, Moriwaki K, Waguri M, Yamamoto K, Miyagawa J, Namba M, Hanafusa T, Matsuzawa Y
Molecular mechanisms of pancreatic beta-cell destruction in autoimmune diabetes: Potential targets for preventive therapy.
Cytokines, Cellular & Molecular Therapy 4: 45-51, 1998

Yamagata K, Yang Q, Yamamoto K, Iwahashi H, Miyagawa J, Okita K, Yoshiuchi I, Miyazaki J, Noguchi T, Nakajima H, Namba M, Hanafusa T, Matsuzawa Y
Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1α is dominant negative.
Diabetes 47: 1231-1235, 1998

Miyagawa J, Yamamoto K, Li M, Sasada R, Igarashi K, Nanmo T, Kitajima K, Moriwaki M, Yamagata K, Nakajima H, Namba M, Hanafusa T, Matsuzawa Y
Duct cell proliferation in the process of islet cell neogenesis induced by betacellulin -Study on the diabetic mice induced by selective alloxan perfusion-.
Endocrinologia 45: 274-275, 1998

Kazuya Yamagata, Toshiaki Hanafusa
Type II diabetes
Molecular Medicine vol 35 special issue Molecular mechanisms of symptoms and pathophysiology p439-441 Yuji Matsuzawa edited by Nakayama Shoten 1998

Kazuya Yamagata, Yuji Matsuzawa
Genetic abnormalities related to adult diseases Diabetes and HNF (Hepatocyte nuclear factor)
Diagnosis and Treatment 86(12): 2093-2098, 1998

Kazuya Yamagata: Basic Lecture I Molecular Genetics
Expression mapping and gene isolation
Diabetes Frontier 9(6): 765-769, 1998

Kazuya Yamagata, Yuji Matsuzawa
Biological significance of hepatocyte nuclear factor (HNF)
Endocrinology and Diabetes 7(4): 347-351, 1998

Kazuya Yamagata, Yuji Matsuzawa
Genes related to maturity-onset diabetes of the young (MODY)
Internal Medicine 82(5): 865-869, 1998

Kazuya Yamagata, Yuji Matsuzawa
MODY1, 3
Advances in Diabetology '98 Vol. 32 p182-188 Edited by the Japan Diabetes Society Diagnosis and Treatment Publishing 1998

Kazuya Yamagata, Toshiaki Hanafusa, Yuji Matsuzawa
HNF-1, HNF-4 and MODY
Advances in Molecular Diabetology - From Basics to Clinical Practice - 1998 p78-83 (supervisor: Yoshio Yazaki) Kinbara Publishing 1998

Kazuya Yamagata, Toshiaki Hanafusa, Yuji Matsuzawa
Onset mechanism of MODY
BIO Clinica 13(4): 300-305, 1998

Koji Yamamoto, Junichiro Miyagawa, Reiko Sasada, Koichi Igarashi, Kazuya Yamagata, Hiroshi Nakajima, Mitsuyoshi Namba, Toshiaki Hanafusa, Yuji Matsuzawa
Altered glucose tolerance and morphological analysis of pancreatic endocrine cells in betacellulin knockout mice
Diabetes Frontier 9 (3): 362, 1998

Kazuya Yamagata, Jin Yang, Kazumasa Yoshiuchi, Toshiaki Hanafusa, Yuji Matsuzawa
HNF gene abnormality and development of MODY
MEDICO 29(6): 12812-12816, 1998

Kazumasa Yoshiuchi, Kazuya Yamagata, Toshiaki Hanafusa, Yuji Matsuzawa
To what extent has the diabetes gene been elucidated?
Medical Practice 15(1): 106-107, 1998

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1997

Kaisaki PJ, Menzel S, Linder T, Oda N, Rjasanowski I, Sahm J, Meincke G, Schulze J, Schmechel H, Petzold C, Ledermann HM, Sachse G, Boriraj VV, Menzel R, Kerner W, Turner RC, Yamagata K , Bell GI
Mutations in the hepatocyte nuclear factor-1 gene in MODY and early-onset NIDDM: Evidence for a mutational hotspot in exon 4.
Diabetes 46: 528-535, 1997.

Vaxillaire M, Rouard M, Yamagata K, Oda N, Kaisaki PJ, Boriraj VV, Chevre JC, Boccio V, Cox RD, Lathrop GM, Dussoix P, Philippe J, Timsit J, Charpentier G, Velho G, Bell GI, Froguel P
Identification of nine novel mutations in the hepatocyte nuclear factor1 alpha gene associated with maturity-onset diabetes of the young (MODY3).
Hum Mol Gen 6: 583-586, 1997.

Urhammer SA, Rasmussen SK, Kaisaki PJ, Oda N, Yamagata K, Moller AM, Fridberg M, Hansen L, Hansen T, Bell GI, Pedersen O
Genetic variation in the hepatocyte nuclear factor-1α gene in Danish Caucasians with late-onset NIDDM.
Diabetologia 40: 473-475, 1997.

Frayling T, Bulman M, Ellard S, Appleton M, Dronsfield MJ, Mackie ADR, Baird JD, Kaisaki PJ, Yamagata K, Bell GI, Bain SC, Hattersley AT
Mutations in the hepatocyte nuclear factor-1α gene are a common cause of maturity-onset diabetes of the young in the United Kingdom.
Diabetes 46: 720-725, 1997.

Iwasaki N, Oda N, Ogata M, Hara M, Hinokio Y, Oda Y, Yamagata K, Kanematsu S, Ohgawara H, Omori Y, Bell GI
Mutations in the hepatocyte nuclear factor-1α /MODY3 gene in Japanese subjects with early- and late-onset NIDDM.
Diabetes 46: 1504-1508, 1997.

Furuta H, Iwasaki N, Oda N, Hinokio Y, Horikawa Y, Yamagata K, Yano N, Sugahiro J, Ogata M, Ohgawara H, Omori Y, Iwamoto Y, Bell GI
Organization and partial sequence of the hepatocyte nuclear factor-4α/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY.
Diabetes 46: 1652-1657, 1997.

Horikawa Y, Iwasaki N, Hara M, Furuta H, Hinokio Y, Cockburn BN, Lindner T, Yamagata K, Ogata M, Tomonaga O, Kuroki H, Kasahara T, Iwamoto Y, Bell GI
Mutation in hepatocyte nuclear factor-1β gene (TCF2) associated with maturity-onset diabetes of the young.
Nature Genet. 17: 384-385, 1997

Qin Yang, Kazumasa Yoshiuchi, Kazuya Yamagata, Hiromi Iwahashi, Koji Yamamoto, Junichiro Miyagawa, Junichi Miyazaki, Hiroshi Nakajima, Mitsuyoshi Namba, Toshiaki Hanabusa, Yuji Matsuzawa
Molecular Diabetology 1997

Kazuya Yamagata, Toshiaki Hanafusa, Yuji Matsuzawa
Recent status of gene search for non-insulin dependent diabetes mellitus
Diabetes Journal 25(4): 153-159, 1997

Kazuya Yamagata, Naoko Iwasaki, Graeme I. Bell
Identification of the NIDDM1 locus
Advances in Molecular Diabetology - From Basics to Clinical Practice - 1997 p77-81 (Editor: Yoshio Yazaki) Kinbara Publishing 1997

Kazuya Yamagata, Yuji Matsuzawa
Gene Mutations and Disease Development
medicina 34(12): 2086-2088, 1997

Kazuya Yamagata, Yuji Matsuzawa
Maturity-onset diabetes of the young (MODY)
Supplementary Volume: History of Medicine Endocrine and Metabolic Diseases-state of arts p465-466 (edited by Yasuo Akanuma, Toshiro Fujita, Takashi Kadowaki) Ishiyaku Publishing Co., Ltd. 1997

Kazuya Yamagata, Yuji Matsuzawa
MODY Onset Genetics
Kazuya Yamagata, Yuji Matsuzawa: Genetic Mutations and Disease Onset
medicina 34(12): 2086-2088, 1997 New Developments in Child Research Shinshin Igaku 52(10): 2393-2397, 1997

Koto Furuta, Kazuya Yamagata, Naohisa Oda, Naoko Iwasaki, Graeme I. Bell
Identification of MODY1 and MODY3 genes
Endocrinology and Diabetes 5(4): 318-324, 1997

Kazuya Yamagata, Naohisa Oda, Koto Furuta, Graeme I. Bell
Is HNF, the causative gene of maturity-onset diabetes of the young (MODY), involved in the onset of diabetes?
Experimental Medicine 15(6): 642-644, 1997

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1996

Iwasaki N, Kawamura M, Yamagata K, Cox NJ, Karibe S, Ohgawara H, Inagaki N, Seino S, Bell GI, Omori Y
Identification of microsatellite markers near the human genes encoding the β-cell ATP-sensitive potassium channel and linkage studies with NIDDM in Japanese.
Diabetes 45: 267-269, 1996.

Gambino V, Menzel S, Trabb JB, Xiang KS, Lindner T, Louit A, Chen E, Mereu LE, Furuta H, Iwasaki N, Kawamura M, Omori Y, Rietzsch H, Schulze J, Schröder HE, Concannon P, Hanis CL, Spielman RS, Yamagata K, Cox NJ, Bell GI
An approach for identifying simple sequences repeat DNA polymorphisms near cloned cDNAs and genes: linkage studies of the islet amyloid polypeptide/amylin and liver glycogen synthase genes and NIDDM.
Diabetes 45: 291-294, 1996.

Yamagata K, Takeda J, Menzel S, Chen X, Eng S, Lim LR, Concannon P, Hanis CL, Spielman RS, Cox NJ, Bell GI
Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle.
Diabetologia 39: 725-730, 1996.

Hanis CL, Boerwinkle E, Chakraborty R, Ellsworth DE, Concannon P, Stirling B, Morrison VA, Wapelhorst B, Spielman RS, Gogolin-Ewens KJ, Shephard JM, Williams SR, Risch N, Hinds D, Iwasaki N, Ogata M, Omori Y, Petzold C, Rietzsch H, Schrüder HE, Schulze J, Cox NJ, Menzel S, Boriraj VV, Chen X, Lim LR, Lindner T, Mereu LE, Wang YQ, Xiang KS, Yamagata K, Yang Y, Bell GI
A genome-wide search for human non-insulin-dependent (Type 2) diabetes mellitus susceptibility genes: evidence for a major susceptibility locus on chromosome 2.
Nature Genet. 13: 161-166, 1996.

Yamagata K, Nakajima H, Tomita K, Itoh N, Miyagawa JI, Hamaguchi T, Namba M, Tamura S, Kawata S, Kono N, Kuwajima M, Noguchi T, Hanafusa T, Matsuzawa Y
Dominant TCR α-chain clonotypes and interferon-γ are expressed in the pancreas of patients with recent-onset insulin-dependent diabetes mellitus.
Diabetes Res. Clin. Pract. 34: 37-46, 1996.

Byrne MM, Sturis J, Menzel S, Yamagata K, Fajans SS, Dronsfield MJ, Bain SC, Hattersley AT, Velho G, Froguel P, Bell GI, Polonsky KS
Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes mellitus susceptibility gene MODY3 on chromosome 12q.
Diabetes 45: 1503-1510, 1996.

Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Turner RC, Velho G, Chevre JC, Froguel P, Bell GI
Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3).
Nature 384: 455-458, 1996

Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M, Bell GI
Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1).
Nature 384: 458-460, 1996

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1995

Takeda J, Fernald AA, Yamagata K, Le Beau MM, Bell GI
Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization.
Genomics 26: 638-639, 1995.

El-Maghrabi MR, Lang AJ, Jiang W, Yamagata K, Stoffel M, Takeda J, Fernald AA, Le Beau MM, Bell GI, Baker L, Pilkis SJ
Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency.
Economics 27: 520-525, 1995.

Itoh N, Hanafusa T, Yamagata K, Nakajima H, Tomita K, Tamura S, Inada M, Kawata S, Kono N, Kuwajima M, Matsuzawa Y
No detectable cytomegalovirus and Epstein-Barr virus genomes in the pancreas of recent-onset IDDM patients.
Diabetologia 38:667-671, 1995.

Menzel S, Yamagata K, Trabb JB, Nerup J, Permutt MA, Fajans SS, Menzel R, Iwasaki N, Omori Y, Cox NJ, Bell GI
Localization of MODY3 to a 5 cm region of human chromosome 12.
Diabetes 44: 1408-1413, 1995.

Kazuya Yamagata, Hiroshi Nakajima, Toshiaki Hanafusa
T cell receptor
Cell Engineering Separate Volume "Medical Experiment Manual Series" Diabetes Research Strategy 47-55, 1995 Shujunsha

Toshiaki Hanafusa, Kazuya Yamagata, Hiroshi Nakashima, Masamichi Kuwashima, Yuji Matsuzawa
TCR of islet-infiltrating T cells in IDDM patients: a study using biopsy pancreatic tissue
Diabetes Record No. 1994 (Edited by Kenji Shima): 258-259, 1995 (Medical Book Publishing)

Hiroshi Nakajima, Naoto Ito, Kazuya Yamagata, Koji Tomita, Toshiaki Hanafusa, Masamichi Kuwashima, Yuji Matsuzawa
Involvement of viruses in IDDM -molecular biological investigation of environmental factors-
Diabetes Record No. 1994 (Edited by Kenji Shima): 260-262, 1995 (Medical Books Publishing)

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1994

Koji Tomita, Hiroshi Nakajima, Toshiaki Hanafusa, Junichiro Miyagawa, Hiromi Iwahashi, Kazuya Yamagata, Tomoya Hamaguchi, Masamichi Kuwashima, Yuji Matsuzawa, Norio Kono, Takehiko Tanaka, Tamio Noguchi
Analysis of the total gene structure of retroviruses expressed in NOD mouse pancreas
Molecular Diabetology 1994 (5): 131-133 Molecular Diabetology Study Group ed. Igaku Tosho Shuppan 1994

Kazuya Yamagata, Hiroshi Nakajima, Toshiaki Hanafusa, Koji Tomita, Naoto Ito, Masamichi Kuwashima, Yuji Matsuzawa
Genetic analysis of infiltrating T-cell receptors in biopsied pancreases from patients with early-onset insulin-dependent diabetes mellitus (IDDM)
Insulin Research 1994 (16): 63064, 1994

Kazuya Yamagata, Toshiaki Hanafusa, Hiroshi Nakajima, Koji Tomita, Naoto Ito, Shinji Tamura, Sumio Kawata, Norio Kono, Masamichi Kuwashima, Yuji Matsuzawa
Genetic analysis of infiltrating T-cell receptors in biopsied pancreases from patients with early-onset insulin-dependent diabetes mellitus (IDDM)
Diabetes Record No. 1993: 235-238, 1994

Toshiaki Hanafusa, Kazuya Yamagata, Hiroshi Nakajima
Analysis of infiltrating T-cell receptor genes in IDDM pancreas
Japan Clinical Journal 52(10): 2767-2771, 1994

Toshiaki Hanafusa, Kazuya Yamagata, Hiroshi Nakajima
Analysis of infiltrating T-cell receptor genes in the pancreas of insulin-dependent diabetic patients
Inflammation and Immunity 2(2): 138-144, 1994

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1993

Nakajima H, Hamaguchi T, Tomita K, Uenaka R, Yamagata K, Hanafusa T, Kuwajima M, Noguchi T, Tanaka T, Kono N, Matsuzawa Y
An alternate nonisotopic technique of PCR-mediated allele-specific oligonucleotide analysis for the detection of a point mutation.
Res. Commun. Chem. Pathol. Pharmacol. 79: 3-10, 1993

Yamagata K, Hanafusa T, Nakajima H, Sato T, Noguchi T, Tomita K, Tsuji K, Kono N, Tanaka T, Tarui S, Kuwajima M, Inoko H, Matsuzawa Y
Overexpression of HLA class 1 antigen reduces insulin secretion in pancreatic βcells (RINm5F): Evidence for a non immune mechanism.
Res. Commun. Chem. Pathol. Pharmacol. 81: 299-308, 1993.

Itoh N, Hanafusa T, Miyazaki A, Miyagawa J, Yamagata K, Yamamoto K, Waguri M, Imagawa A, Tamura S, Inada M, Kawata S, Tarui S, Kono N, Matsuzawa Y
Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.
J. Clin. Invest. 92: 2313-2322, 1993.

Akihisa Imagawa, Naoto Ito, Toshiaki Hanafusa, Atsushi Miyazaki, Hiroyuki Miki, Junichiro Miyagawa, Kazuya Yamagata, Masako Waguri, Shinji Tamura, Mitsuyoshi Namba, Sumio Kawata, Masamichi Kuwashima, Norio Kono, Yuji Matsuzawa
A case of insulin-dependent diabetes mellitus with CD8+ T lymphocyte-dominant insulitis -Study in biopsy pancreatic tissue-
Diabetes, 36(11), 875-880, 1993

Norio Kono, Toshiaki Hanafusa, Masako Waguri, Naoto Ito, Kazuya Yamagata, Hiroshi Nakajima, Junichiro Miyagawa
Elucidation of the cause of IDDM by analysis of pancreatic islet lesions in patients
Ministry of Health and Welfare "Diabetes research" 1992 report Research on the pathogenesis of diabetes: 168-172, 1993

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1992

Kazuya Yamagata, Toshiaki Hanafusa
Genetic analysis of IDDM
Recent progress
Pharma Medica 10(8): 27-31, 1992


1991

Yamagata K, Hanafusa T, Nakajima H, Sada M, Amemiya H, Noguchi T, Tanaka T, Kono N, Tarui S
HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.
Diabetologia 34: 133 136, 1991.

Yamagata K, Hanafusa T, Nakajima H, Sada M, Amemiya H, Tomita K, Miyagawa J, Noguchi T, Tanaka T, Kono N, Tarui S
HLA-DP and susceptibility to insulin-dependent diabetes mellitus in Japanese.
Tissue Antigens 38: 107-110, 1991.

Noguchi T, Yamada K, Yamagata K, Takenaka M, Nakajima H, Imai E, Wang Z, Tanaka T
Expression of liver type pyruvate kinase in insulinoma cells: Involvement of LF-B1 (HNF1).
Biochem. Biophys. Res. Commun. 181: 259-264, 1991.

Naoto Ito, Toshiaki Hanafusa, Junichiro Miyagawa, Shinji Tamura, Masami Inada, Hayato Katsura, Kazuya Yamagata, Sumio Kawata, Norio Kono, Seiichiro Tarui
Role of cell adhesion molecules ICAM-1 and LFA-3 in the development of insulin-dependent diabetes mellitus (IDDM) -Study in endothelial cells of biopsied pancreatic tissue-
Peptide Hormones in Pancreas, 11, 103-106, 1991

Kazuya Yamagata, Toshiaki Hanafusa, Hiroshi Nakashima, Norio Kono, Seiichiro Tarui
Analysis of HLA-DQA, DQB, and TNF genes in Japanese insulin-dependent diabetic patients
Molecular Diabetology 2: 13-17, 1991

Kazuya Yamagata, Toshiaki Hanafusa, Norio Kono
DQ genes and IDDM
Diabetes J. 19(3): 85-91, 1991

Kazuya Yamagata, Toshiaki Hanafusa
Insulin-dependent diabetes and MHC
Japan Clinical Journal 49 (special edition): 525-530, 1991

Kazuya Yamagata, Toshiaki Hanafusa
Etiology of autoimmune endocrine diseases: MHC
Pharma Medica 9(5): 43-48, 1991

Kazuya Yamagata, Toshiaki Hanafusa
Q&A
Diabetes Frontier 2(5): 629, 1991

Kazuya Yamagata, Toshiaki Hanafusa, Junichiro Miyagawa, Norio Kono, Seiichiro Tarui
Pathogenesis and molecular biology of IDDM
Overview Diabetes Frontier 2(1): 29-33, 1991

Hayato Katsura, Junichiro Miyagawa, Nobuaki Watanabe, Yoshiya Komatsu, Hiroshi Fujii, Chisa Nakagawa, Koji Yamamoto, Kazuya Yamagata, Mamiko Tsugawa, Hidehiko Ito, Koji Tajima, Mitsuyoshi Namba, Toshiaki Hanabusa, Norio Kono, Kaname Moriwaki, Seiichiro Tarui
A case of thymic carcinoid and MEN type 1 treated with a somatostatin analogue (SMS201-995)
Hormone and Clinical 39: 292-295, 1991

Toshiaki Hanafusa and Kazuya Yamagata
Regulation of endocrine cell MHC gene expression by cytokines
Importance in the development of autoimmune endocrine diseases Kato Memorial Intractable Disease Research Fund Grant Research Report 3: 17-24, 1991

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1990

Yamagata K, Hanafusa T, Nakajima H, Miyagawa J, Miyazaki A, Kono N, Tarui S
Expression of MHC antigens on islet cells in insulin-dependent diabetes mellitus: Analysis of pancreas biopsy specimens and RINm5F cells.
Recent trends of diabetes mellitus in East Asia (G. Mimura, C.Zhisheng eds.): 73-76, 1990 (Elsevier Science Pub., Amsterdam).

Kiyokawa H, Namba M, Miyazaki A, Yamagata K, Tajima K, Miyagawa J, Kono N, Tarui S
Nocturnal increase in urinary epinephrine excretion in IDDM treated with intensive insulin therapy: A clinical indicator of asymptomatic hypoglycemia.
Current Proc. 3rd Int. Symp. Treatment of Diabetes Mellitus (N.Sakamoto, KGMM Alberti, N. Hotta eds): 681-685, 1990 (Elsevier Science Pub., Amsterdam).

Hanafusa T, Miyazaki A, Miyagawa J, Tamura S, Inada M, Yamada K, Shinji Y, Katsura H, Yamagata K, Itoh N, Asakawa H, Nakagawa C, Otsuka A, Kawata S, Kono N, Tarui S
Examination of islets in the pancreas biopsy specimens from newly diagnosed Type 1 (insulin-dependent) diabetic patients.
Diabetologia 33: 105-111, 1990.

Miyagawa J, Yamamoto K, Hanafusa T, Itoh N, Nakagawa C, Otsuka A, Katsura H, Yamagata K, Miyazaki A, Kono N, Tarui S
Preventive effect of a new immuno suppressant FK-506 on insulitis and diabetes in non-obese diabetic mice.
Diabetologia 33:503-505, 1990.

Asakawa H, Miyagawa J, Hanafusa T, Katsura H, Miyazaki A, Otsuka A, Nakagawa C, Yamagata K, Tajima K, Mashita K, Kono N, Tarui S
Interferon-γ reduces actin filaments and inhibits thyroid-stimulating hormone-induced formation of microvilli and pseudopods in mouse monolayer thyrocytes. Endocrinology 127: 325-329, 1990.

Kazuya Yamagata, Toshiaki Hanafusa
Pathogenesis of insulin-dependent diabetes
Japanese Clinical Special Issue, Clinical Immunology (Second Volume) 48: 426-430, 1990

Kazuya Yamagata, Toshiaki Hanafusa, Hiroshi Nakashima, Norio Kono, Seiichiro Tarui
Analysis of HLA class II genes in Japanese IDDM
Molecular Diabetology 1990 vol1, p27-30 Molecular Diabetology Study Group ed. Igaku Tosho Shuppan 1990

Junichiro Miyagawa, Koji Yamamoto, Toshiaki Hanafusa, Hayato Katsura, Naoto Ito, Chisa Nakagawa, Kazuya Yamagata, Norio Kono, Seiichiro Tarui
Effect of immunosuppressant FK-506 on insulitis and onset of diabetes in NOD mice
Diabetic Animal 4 p205-210, Diabetic Animal Study Group ed. Medical Journal 1990

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1989

Yamagata K, Nakajima H, Hanafusa T, Noguchi T, Miyazaki A, Miyagawa J, Sada M, Amemiya H, Tanaka T, Kono N, Tarui S
Aspartic acid at position 57 of DQβ chain does not protect against Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.
Diabetologia 32: 762-764, 1989.

1988

Junichiro Miyagawa, Toshiaki Hanafusa, Atsushi Miyazaki, Hayato Katsura, Hideki Asakawa, Akihito Otsuka, Chisa Nakagawa, Kazuya Yamagata, Naoto Ito, Norio Kono, Seiichiro Tarui, Yoshihiro Togano
Diabetic glomerular lesions in long-lived NOD mice with insulin treatment
Diabetic animals 2 p190-194, edited by Yoshio Goto Journal of Medicine, Dentistry and Medicine 1988

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