​ 業績

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2020年

Sato Y, Rahman MM, Haneda M, Tsuyama T, Mizumoto T, Yoshizawa T, Kitamura T, Gonzalez FJ, Yamamura KI, Yamagata K.

HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1.

Biochim Biophys Acta Mol Basis Dis. 2020 Jul 22;1866(11):165898. In press

Kariba Y, Yoshizawa T, Sato Y, Tsuyama T, Araki E, Yamagata K.

Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes.

Biochem Biophys Res Commun. 2020 In press.

Yamamura S, Izumiya Y, Araki S, Nakamura T, Kimura Y, Hanatani S, Yamada T, Ishida T, Yamamoto M, Onoue Y, Arima Y, Yamamoto E, Sunagawa Y, Yoshizawa T, Nakagata N, Bober E, Braun T, Sakamoto K, Kaikita K, Morimoto T, Yamagata K, Tsujita K.

Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4.

Hypertension 75(1):98-108, 2020

2019年

Sobuz SU, Sato Y, Yoshizawa T, Karim F, Ono K,Sawa T,Miyamoto Y,Oka M,Yamagata K
SIRT7 regulates the nuclear export of NF-κB p65 by deacetylating Ran.
Biochim Biophys Acta Mol Cell Res. 1866(9):1355-1367, 2019


2018年

Fukuda M,Yoshizawa T,Karim MF,Sobuz SU,Korogi W,Kobayasi D,Okanishi H,Tasaki M,Ono K,Sawa T,Sato Y,Chirifu M,Masuda T,Nakamura T,Tanoue H, Nakashima K,Kobashigawa Y,Morioka H,Bober E,Ohtsuki S,Yamagata Y,Ando Y,Oike Y,Araki N,Takeda S,Mizuta H,Yamagata K
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.
Nat Commun. 9(1):2833, 2018

Miyasato Y, Yoshizawa T, Sato Y, Nakagawa T, Miyasato Y, Kakizoe Y, Kuwabara T, Adachi M, Ianni A, Braun T, Komohara Y, Mukoyama M, Yamagata K
Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response.
Scientific Reports 8:5927, 2018

Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishi N, Fukuda K, Murakami S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Yamagata K, Takeya M, Araki E
Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis and insulin resistance.
Arterioscler Thromb Vasc Biol.38:994-1006, 2018

Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K
SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.
Biochem Biophys Res Commun. 496:891-97, 2018

Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, Endo M, Zhu S, Fan H, Horiguchi H, Morinaga J, Terada K, Yoshizawa T, Yamagata K, Oike Y
Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice.
J Biol Chem. 293:1596-1609,2018

Islam MS, Wei FY, Ohta K, Shigematsu N, Fukuda T, Tomizawa K, Yoshizawa T, Yamagata K
Sirtuin 7 is involved in the consolidation of fear memory in mice.
Biochem Biophys Res Commun. 495:261-66, 2018

Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y
Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.
Osteoarthr Cartilage 26: 108-117, 2018

Yamagata K, Yoshizawa T
Transcriptional regulation of metabolism by SIRT1 and SIRT7.
Int Rev Cell Mol Biol.335:143-166, 2018


2017年

Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K
Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.
Biochem Biophys Res Commun. 490:423-28, 2017

Sato Y, Tsuyama T, Sato C, Karim MF, Yoshizawa T, Inoue M, Yamagata K
Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase.
J Biol Chem. 292:8716-28, 2017

Nomiyama H, Osada N, Takahashi I, Terao K, Yamagata K, Yoshie O
Translational repression of a splice variant of cynomolgus macaque CKCL1L by its C-terminal sequence.
J Interferon Cytokine Res.37:129-138, 2017


2016年

Jono H, Su Y, Obayashi K, Tanaka Y, Ishiguro A, Nishimura H, Shinriki S, Ueda M, Ikeda K, Yamagata K, Ichihara K, Ando Y
Sources of variation of transthyretin in healthy subjects in East and Southeast Asia: Clinical and experimental evidence for the effect of alcohol on transthyretin metabolism.
Clin Chim Acta. 458:5-11, 2016


2015年

Araki S, Izumiya Y, Rokutanda T, Ianni A, Hanatani S, Kimura Y, Onoue Y, Senokuchi T, Yoshizawa T, Yasuda O, Koitabashi N, Kurabayashi M, Braun T, Bober E, Yamagata K, Ogawa H
Sirt7 contributes to myocardial tissue repair by maintaining TGF-b signaling pathway.
Circulation 132:1081-1093, 2015

Yamagata K, Karim MF, Sato Y, Yoshizawa T
Role of SIRT7 in hepatic lipid metabolism.
Diabetol Int. 6:193-196, 2015

Yoshikawa Y, Yoshizawa T, Domae E, Hieda Y, Takeyama A, Hirota S, Kawamoto A, Goda S, Tamura I, Kamada A, Komasa Y, Morita S, Yamagata K, Ikeo T
RNA interference-mediated knockdown of Smad1 inhibits receptor activator of nuclear factor kB ligand expression induced by BMP-2 in primary osteoblasts.
Arch Oral Biol 60:1319-1326, 2015

Kurokawa H, Ito H, Inoue M, Tabata K, Sato Y, Yamagata K, Kizaka-Kondoh S, Kadonosono T, Yano S, Inoue M, Kamachi T
High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime.
Scientific Reports 5:10657, 2015

Hayashi H, Sato Y, Li Z, Yamamura KI, Yoshizawa T, Yamagata K
Roles of hepatic glucokinase in intertissue metabolic communication: examination of novel liver-specific glucokinase knockout mice.
Biochem Biophys Res Commun. 460:727-32, 2015


2014年

Sato Y, Inoue M, Yoshizawa T, Yamagata K.
Moderate hypoxia induces b-cell dysfunction with HIF-1–independent gene expression changes.
PLOS ONE 9:e114868,2014

Ohki T, Utsu Y, Morita S, Karim MF, Sato Y,Yoshizawa T, Yamamura K , Yamada K, Kasayama S, Yamagata K.
Low serum level of high-sensitivity C-reactive protein in a Japanese patient with maturity-onset diabetes of the young type 3 (MODY3)
J Diabetes Invest. 5:513-516,2014

Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E,Takaaki Akaike T, Braun T, Oike Y,Bober E,Yamagata K
SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway.
Cell Metabolism 19:712-721,2014

Yamagata K
Roles of HNF1α and HNF4α in pancreatic β-cells: lessons from a monogenic form of diabetes (MODY).
Vitam Horm. 95:407-423,2014


2013年

Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, Sekine K, Sato T, Kawano H, Aihara K, Nakamichi Y, Watanabe T, Shindo M, Inoue K, Inoue E, Tsuji N, Hoshino M, Karsenty G, Metzger D, Chambon P, Kato S, Imai Y
Vitamin D receptor in osteoblasts is a negative regulator of bone mass control.
Endocrinology 154:1008-1020, 2013

Kozawa J, Okita K, Iwahashi H, Yamagata K, Imagawa A, Shimomura I
Early postprandial glucagon surge affects postprandial glucose levels in obese and non-obese patients with type 2 diabetes.
Endocr J.60(6):813-818,2013

Karim MF, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, Akaike T, Yamagata K
Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a(Mybbp1a)
Biochem Biophys Res Commun. 441:157-163,2013

山縣和也
脂肪酸の種類と脂肪酸合成経路
内分泌・糖尿病・代謝内科 36:467-470, 2013


2012年

Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, Yamagata K
Anks4b, a novel target of HNF4α interacts with GRP78 and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.
J.Biol Chem. 287:23236-45,2012

Ohki T, Sato Y, Yoshizawa T, Yamamura KI, Yamada K, Yamagata K
Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells.
Biochem Biophys Res Commun. 425(3):619-24,2012

Su Y, Misumi Y, Ueda M, Shono M, Tasaki M, Jono H, Obayashi K, Senokuchi T, Yamagata K, Ando Y
The occurrence of islet amyloid polypeptide amyloidosis in Japanese subjects.
Pancreas. 41: 971-973,2012

Su Y, Jono H, Misumi Y, Senokuchi T, Guo J, Ueda M, Shinriki S, Tasaki M, Shono M, Obayashi K, Yamagata K, Araki E, Ando Y
Novel function of transthyretin in pancreatic a cells.
FEBS Letters. 586: 4215-4222,2012

佐藤叔史、山縣和也、井上正宏
低酸素と糖尿病、癌
内分泌・糖尿病・代謝内科35: 264-269, 2012

佐藤叔史、山縣和也
膵β細胞における低酸素応答と糖代謝異常
実験医学増刊 活性酸素・ガス状分子による恒常性制御と疾患 監修:山本雅之、 羊土社:146-152,2012

山縣和也
MODY
小児・思春期糖尿病の対応マニュアル 編集:池上博司、中山書店:81-87,2012

山縣和也
膵β細胞の分化にかかわる転写因子と生活習慣病-転写因子と糖尿病-
別冊・医学のあゆみ エネルギー代謝転写因子ネットワークと生活習慣病 編集:島野仁
医歯薬出版株式会社:60-64,2012

山縣和也
テーラーメイド医療に必要な基礎知識:単一遺伝子による糖尿病(MODY)
月刊糖尿病6:112-116,2012


2011年


Iwahashi H, Akita E, Tokunaga A, Okita K, Horikawa Y, Imagawa A, Funahashi T, Shimomura I, Yamagata K
Clinical features of Japanese type 2 diabetics with insulinogenic index in normal range after treatment of glucotoxicity.
Diabetol Int. 2. 208-213,2011

Wei F-Y, Suzuki T, Watanabe S, Kimura S, Kaitsuka T, Fujimura A, Matsui H, Atta M, Michiue H, Fontecave M, Yamagata K, Suzuki T, Tomizawa K
Deficit of Lys-tRNA Modification by Cdkal1 Causes the Development of Type 2 Diabetes in Mice.
J. Clin. Invest. 121: 3598-3608, 2011

Yano M, Watanabe K, Yamamoto T, Ikeda K, Senokuchi T, Lu M, Kadomatsu T, Tsukano H, Ikawa M, Okabe M, Yamaoka S, Okazaki T, Umehara H, Gotoh T, Song WJ, Node K, Taguchi R, Yamagata K, Oike Y
Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1 null mice.
J Biol Chem. 286: 3992-4002, 2011

Sato Y, Endo H, Okuyama H, Takeda T, Iwahashi H, Imagawa A, Yamagata K, Shimomura I, Inoue M
Cellular hypoxia of pancreatic β-cells due to high levels of oxygen consumption for insulin secretion in vitro.
J Biol.Chem. 286: 12524-12532, 2011

Yamagata K, Senokuchi T, Lu M, Takemoto M, Karim MF, Go C, Sato Y, Hatta M, Yoshizawa T, Araki E, Miyazaki J, Song W-J
Voltage-gated K+ channel KCNQ1 regulates insulin secretion in MIN6 β-cell line.
Biochem Biophys Res Commun. 407: 620-625, 2011

山縣和也
膵β細胞の分化にかかわる転写因子と生活習慣病-転写因子と糖尿病-
医学のあゆみ237 (6):672-676,2011


2010年

Kozawa J, Okita K, Imagawa A, Iwahashi H, Holst JJ, Yamagata K, Shimomura I
Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes.
Biochem Biophys Res Commun. 393: 410-413, 2010

Higuchi Y, Shiraki N, Yamane K, Qin Z, Mochitate K, Araki K, Senokuchi T, Yamagata K, Hara M, Kume K, Kume S
Synthesized basement membranes direct the differentiation of mouse embryonic stem cells into pancreatic lineages.
J Cell Sci. 123: 2733-2742, 2010

山縣和也
MODY遺伝子異常と糖尿病
糖尿病 診断基準2010-臨床での応用と実際- 糖尿病レクチャー1:447-452, 2010

山縣和也
HNFファミリーとアディポサイエンス
Adiposcience「核内受容体とアディポサイエンス」7: 162-167, 2010

山縣和也
核内受容体と糖尿病
ホルモンと臨床「核内受容体と内分泌疾患UPDATE」58: 137-141, 2010

山縣和也
転写因子によるβ細胞機能の調節
糖尿病ナビゲーター第2版 pp36-37、門脇 考編、メディカルレビュー社2010

山縣和也
単一遺伝子病タイプの糖尿病遺伝子
医学のあゆみ 232: 1173-1177, 2010


2009年

Miyake K, Yang W, Hara K, Yasuda K, Horikawa Y, Osawa H, Furuta H, Ng M CY, Hirota Y, Mori H, Ido K, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamda Y, Seino Y, Maegawa H, Kashiwagi A, Wang Hy, Tanahashi T, Nakamura N, Takeda J, Maeda E, Yamamoto K, Tokunaga K, Ma RCW, So W-Y, Chan JCN, Kamatani N, Makino H, Nanjo K, Kadowaki T, Kasuga M
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on eleven genes with strong evidence of the association.
J Hum Genet. 54: 236-241, 2009

Okauchi Y, Nammo T, Iwahashi H, Kizu T, Hayashi I, Okita K, Yamagata K, Uno S, Katsube F, Matsuhisa M, Kato K, Aozasa K, Kim T, Osuga K, Nakamori S, Tamaki Y, Funahashi T, Miyagawa J, Shimomura I
Glucagonoma diagnosed by arterial stimulation and venous sampling (ASVS).
Intern Med. 48: 1025-1030, 2009

Saisho K, Fukuhara A, Yasuda T, Sato Y, Fukui K, Iwahashi H, Imagawa A, Hatta M, Shimomura I, Yamagata K
Glucose enhances collectrin protein expression in insulin-producing MIN6 β cells.
Biochem. Biophys. Res. Commun. 389: 133-137, 2009

山縣和也
糖尿病と遺伝子
糖尿病学の進歩2009 第43集 pp73-76,日本糖尿病学会編 診断と治療社2009

山縣和也
糖尿病性ケトアシドーシス
今日の治療指針2009 医学書院 pp541-542,2009

山縣和也
核:核内転写因子と糖尿病
Diabetes Frontier メディカルレビュー社 1(20):109-113,2009


2008年

Miyake K, Horikawa Y, Hara K, Yasuda K, Osawa H, Furuta H, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J, Makino H, Nanjo K, Kadowaki T, Kasuga M
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
J Hum Genet. 53: 174-180, 2008

Nagai R, Fujiwara Y, Mera K, Yamagata K, Sakashita N, Takeya M
Immunochemical detection of Nε-carboxyethyl lysine using a specific antibody.
J Immunol Methods 332: 112-120, 2008

Tokunaga A, Miura A, Okauchi Y, Segawa K, Fukuhara A, Okita K, Takahashi M, Funahashi T, Miyagawa JI, Shimomura I, Yamagata K
The -1535 promoter variant of the visfatin gene is associated with serum triglyceride and HDL-cholesterol levels in Japanese subjects.
Endocr J. 55: 205-212, 2008

Horikawa Y, Miyake K, Yasuda K, Enya M, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J, Kasuga M
Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan.
J Clin Endocrinol Metab. 93: 889-893, 2008

Okauchi Y, Iwahashi H, Okita K, Yuan M, Matsuda M, Tanaka T, Miyagawa J, Funahashi T, Horikawa Y, Shimomura I, Yamagata K
PGC-1α Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men.
Endocr J. 55: 991-997, 2008

Tamba S, Nishizawa H, Funahashi T, Okauchi Y, Ogawa T, Noguchi M, Fujita K, Ryo M, Kihara S, Iwahashi H, Yamagata K, Nakamura T, Shimomura I, Matsuzawa Y
Relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men.
Intern Med. 47:1175-1180, 2008

Tokunaga A, Horikawa Y, Fukuda-Akita E, Okita K, Iwahashi H, Shimomura I, Takeda J, Yamagata K
A common P2 promoter polymorphism of the hepatocyte nuclear factor-4a gene is associated with insulin secretion in non-obese Japanese with type 2 diabetes.
Endocr J. 55: 999-1004, 2008

Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamda Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, So WY, Chan JC, Lyssenko Y, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.
Nat Genet. 40: 1092-1097, 2008

Enya M, Horikawa Y, Kuroda E, Yonemura K, Tonooka N, Tomura H, Oda N, Yokoi N, Yamagata K, Shihara N, Iizuka K, Saibara T, Seino S, Takeda J
Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients.
Hum Mutat. 29: E271-277, 2008

Yasuhara A, Wada J, Malakauskas SM, Zhang Y, Eguchi J, Nakatsuka A, Murakami K, Kanzaki M, Teshigawara S, Yamagata K, Le TH, Makino H
Collectrin is involved in the development of salt-sensitive hypertension by facilitating the membrane trafficking of apical membrane proteins via interaction with soluble N-ethylmaleiamide-sensitive factor attachment protein receptor complex.
Circulation 118: 2146-2155, 2008

Fukuda-Akita E, Okita K, Okauchi Y, Ryo M, Nakamura T, Funahashi T, Iwahashi H, Shimomura I, Miyagawa J, Yamagata K
Impaired early insulin secretion in Japanese type 2 diabetes with metabolic syndrome.
Diabetes Res Clin Pract 79: 482-489, 2008

Nammo T, Yamagata K, Tanaka T, Kodama T, Sladek FM, Fukui K, Katsube F, Sato Y, Miyagawa J, Shimomura I
Expression of HNF-4α (MODY1), HNF-1α (MODY5), and HNF-1α (MODY3) proteins in the developing mouse pancreas.
Gene Expr Patterns. 8: 96-106, 2008

山縣和也
糖尿病関連転写因子
転写制御とエピジェネティクス -ゲノムデコードに向けて- P189-195 南山堂 2008

山縣和也
転写因子異常によるインスリン合成分泌障害
糖尿病学の進歩2008 第42集 p10-13, 日本糖尿病学会編 診断と治療社 2008

山縣和也
コレクトリン
-新時代の糖尿病学- 日本臨床66巻増刊号9,673-677,2008

山縣和也
糖代謝における核内受容体の意義 
分子心血管病 先端医学社 33(255)-37(259),2008

山縣和也
MODY遺伝子に関する最近の知見 -治療法の選択も含めて-
DIABETES JOURNAL 糖尿病と代謝 36(2):1-6,2008 

山縣和也
核内受容体と糖尿病
ゲノム医学 メディカルレビュー社 8(1):49-53,2008

山縣和也
単一遺伝子異常による糖尿病 MODY遺伝子 進時代の糖尿病学(1) -病因・診断・治療研究の進歩-
日本臨床 66巻増刊号3,p514-520,2008

山縣和也
糖代謝に関わる転写因子と2型糖尿病の膵β細胞機能障害
2型糖尿病における膵β細胞研究の進歩 編集:寺内康夫 p59-66, 診断と治療社2008


2007年

Uno S, Imagawa A, Okita K, Sayama K, Moriwaki M, Iwahashi H, Yamagata K, Tamura S, Matsuzawa Y, Hanafusa T, Miyagawa J, Shimomura I
Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-alpha in patients with recent-onset type 1 diabetes.
Diabetologia. 50: 596-601, 2007

Zhang Y, Wada J, Yasuhara A, Iseda I, Eguchi J, Fukui K, Yang Q, Yamagata K, Hiesberger T, Igarashi P, Zhang H, Wang H, Akagi S, Kanwar YS, Makino H
The Role for HNF-1β-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells.
PLoS ONE. 2: e414, 2007.

Okauchi Y, Nishizawa H, Funahashi T, Ogawa T, Noguchi M, Ryo M, Kihara S, Iwahashi H, Yamagata K, Nakamura T, Shimomura I, Matsuzawa Y
Reduction of visceral fat is associated with decrease in the number of metabolic risk factors in Japanese men.
Diabetes Care. 30: 2392-2394, 2007

Zhang J, Tokui Y, Yamagata K, Kozawa J, Sayama K, Iwahashi H, Okita K, Miuchi M, Konya H, Hamaguchi T, Namba M, Shimomura I, Miyagawa JI
Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes.
Diabetologia 50: 1900-1909, 2007

Yamagata K, Nammo T, Sato Y, Saisho K, Shoda H, Fukui K
The HNF-1α-SNARE connection. Diabetes Obes Metab.
Suppl 2: 40-45, 2007

山縣和也
インスリン開口放出におけるコレクトリンの役割
内分泌・糖尿病科 25(3): 229-232, 2007

岩橋博見、山縣和也
インスリン分泌促進薬
糖尿病関連注射薬の新展開(インスリン・GLP-1・グルカゴン) pp79-82  編集:難波光義

山縣和也
MODY総論およびHNF異常症
糖尿病学 基礎と臨床 pp364-367 編集:門脇孝、石橋俊、佐倉宏、戸辺一之、野田光彦 西村書店2007

山縣和也
転写因子による膵β細胞機能の調節
糖尿病学 基礎と臨床 pp31-33 編集:門脇孝、石橋俊、佐倉宏、戸辺一之、野田光彦 西村書店2007

山縣和也
インスリン分泌のapparatus メタボリックシンドローム時代の糖尿病研究の最前線
医学のあゆみ 220(13): 1134-1137, 2007

山縣和也
単一遺伝子病とゲノム-若年性糖尿病MODY-
ゲノム医学 7(2): 69-74, 2007

山縣和也
2型糖尿病の薬物療法:その病態に合致する薬剤
ジョスリン糖尿病デスクブック(翻訳) 監訳:松澤佑次 医学書院2007

山縣和也
糖尿病原因遺伝子
現場の疑問に答える糖尿病診療Q&A pp380-381 編集:寺内康夫 中外医学社2007

山縣和也
新規HNF-1 標的遺伝子コレクトリンによるβ細胞機能制御
糖尿病学2007 pp69-74 編集:岡芳知、谷澤幸生 診断と治療社2007

山縣和也、福井健司
コレクトリンとインスリン分泌
分子糖尿病学の進歩2007 pp2-7 編集:春日雅人、清野進、渥美義仁、門脇孝 金原出版2007

山縣和也
転写因子HNFとコレクトリン
糖尿病学の進歩2007 pp7-10 編集:日本糖尿病学会 診断と治療社2007

山縣和也
コレクトリン
内分泌・糖尿病科 24(1): 76-79, 2007


2006年

Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I
Hepatocyte nuclear factor-4α is essential for glucose-stimulated insulin secretion by pancreatic β-cells.
J Biol Chem. 281: 5246-5257, 2006

Tokui Y, Kozawa J, Yamagata K, Zhang J, Ohmoto H, Tochino Y, Okita K, Iwahashi H, Namba M, Shimomura I, Miyagawa J
Neogenesis and proliferation of beta-cells induced by human betacellulin gene transduction via retrograde pancreatic duct injection of an adenovirus vector.
Biochem Biophys Res Commun. 350: 987-993, 2006

山縣和也、福井健司:コレクトリン
検査と技術 34 (13): 1537-1538, 2006

山縣和也、福井健司:コレクトリンによるインスリン分泌機構
Diabetes Journal 34 (4): 163-164, 2006

山縣和也
転写因子HNFと糖尿病
糖尿病学の進歩2006 pp143-148 編集:日本糖尿病学会 診断と治療社2006

山縣和也
Maturity-onset diabetes of the young (MODY)
最新糖尿病学ー基礎と臨床ー pp187-194 編集:垂井清一郎、門脇 孝、花房俊昭 朝倉書店2006

山縣和也
MODYと転写因子
内分泌・糖尿病科23(1): 101-107, 2006

山縣和也
転写因子異常と糖尿病
Pharma medica 24 (4): 47-52, 2006


2005年

Ozawa K, Miyazaki M, Matsuhisa M, Takano K, Nakatani Y, Hatazaki M, Tamatani T, Yamagata K, Miyagawa J, Kitao Y, Hori O, Yamasaki Y, Ogawa S
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.
Diabetes 54: 657-663, 2005

Ihara A, Yamagata K, Nammo T, Miura A, Ming Y, Tanaka T, Sladek FM, Matsuzawa Y, Miyagawa J, Shimomura I
Functional characterization of the HNF4 isoform (HNF4 8) expressed in pancreatic β-cells.
Biochem Biophys Res Commun. 329: 984-990, 2005

Kozawa J, Tokui Y, Moriwaki M, Li M, Ohmoto H, Yuan M, Zhang J, Iwahashi H, Imagawa A, Yamagata K, Tochino Y, Shimomura I, Higashiyama S, Miyagawa J
Regenerative and therapeutic effects of heparin-binding epidermal growth factor-like growth factor on diabetes by gene transduction via retrograde pancreatic duct injection of adnovirus vector.
Pancreas 31: 32-42, 2005

Sayama K, Imagawa A, Okita K, Uno S, Moriwaki M, Kozawa J, Iwahashi H, Yamagata K, Tamura S, Matsuzawa Y, Hanafusa T, Miyagawa J, Shimomura I
Pancreatic beta and alpha cells are both decreased in patients with fulminant type 1 diabetes: a morphometrical assessment.
Diabetologia 48: 1560-1564, 2005

Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K
The HNF-1 target Collectrin controls insulin exocytosis by SNARE complex formation.
Cell Metab. 2: 373-384, 2005

中田信輔、岩橋博見、寺前純吾、紺屋浩之、袁明、沖田考平、今川彰久、浜口朋也、山縣和也、下村伊一郎、宮川潤一郎、難波光義、花房俊昭
速効型から超速効型インスリン製剤への変更による血糖改善効果と内因性インスリン分泌能との関連
糖尿病 第48巻第10号、733-738 糖尿病学用語集 第2版 (用語解説者: 山縣和也)日本糖尿病学会編、文光堂2005

山縣和也
MODY遺伝子
Diabetes Frontier 16 (5): 561-566, 2005

山縣和也
MODY (HNFファミリー)
糖尿病と遺伝子(糖尿病カレントライブラリー)pp22-27 編集:堀川幸男、安田和基 文光堂2005

山縣和也
糖尿病易発症疾患感受性遺伝子多型
HNF-1α遺伝子G319S多型
耐糖能障害 -基礎・臨床研究の最新情報- 日本臨床63巻増刊号2:171-175, 2005


2004年

Shimamoto Y, Ishida J, Yamagata K, Saito T, Kato H, Matsuoka T, Hirota K, Daitoku H, Nangaku M, Yamagata K, Fujii H, Takeda J, Fukamizu A
Inhibitory effect of small heterodimer partner on hepatocyte nuclear factor 4 mediates bile acid-induced repression of human angiotensinogen gene.
J. Biol. Chem. 279: 7770-7776, 2004

Tomimoto S, Hashimoto H, Shintani N, Yamamoto K, Kawabata Y, Hamagami K, Yamagata K, Miyagawa J, Baba A
Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice.
J. Pharmacol. Exp. Ther. 309: 796-803, 2004

岡内幸義、南茂隆生、岩橋博見、椿尾真弓、芳川篤志、林功、沖田考平、加藤研、松久宗英、山崎義光、山縣和也、船橋徹、宮川潤一郎、下村伊一郎
経過中インスリン分泌能およびインスリン抵抗性指標を追跡し得たヘモクロマトーシス合併糖尿病の1症例
Diabetes Journal 32(3):90-94,2004

山縣和也:転写因子異常による糖尿病:HNF diabetes
医学のあゆみ211 (2): 163-166, 2004

山縣和也:HNF遺伝子ファミリーと糖尿病
糖尿病47 (7): 504-507, 2004

山縣和也
HNF-1 異常型糖尿病 (MODY3)
糖尿病100例に学ぶ 編集:河盛隆造、山崎義光 永井書店2004

山縣和也
MODY遺伝子:HNFファミリー
医学のあゆみ 糖尿病・代謝症候群-state of arts 2004-2006 編集:門脇 孝 医歯薬出版2004

山縣和也
HNF
糖尿病ライブラリー「インスリン分泌」pp133-137 編集:岡 芳知 文光堂2004


2003年

Zhu Q, Yamagata K, Miura A, Shihara N, Horikawa Y, Takeda J, Miyagawa J, Matsuzawa Y
T130I mutation in HNF-4 gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects.
Diabetologia 46: 567-573, 2003

Yamamoto K, Hashimoto H, Tomimoto S, Shintani N, Miyazaki J, Tashiro F, Aihara H, Nammo T, Li M, Yamagata K, Miyagawa J, Matsuzawa Y, Kawabata Y, Fukuyama Y, Koga K, Mori W, Tanaka K, Matsuda T, Baba A
Overexpression of PACAP in transgenic mouse pancreatic cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes.
Diabetes 52: 1155-1162, 2003

Yamagata K: Regulation of pancreatic -cell function by the HNF transcription network
Lessons from maturity-onset diabetes of the young (MODY).
Endocr J. 50: 491-499, 2003

Iwahashi H, Funahashi T, Kurokawa N, Sayama K, Fukuda E, Okita K, Imagawa A, Yamagata K, Shimomura I, Miyagawa J, Mtsuzawa Y
Plasma adiponectin levels in women with anorexia nervosa. Horm.
Metab. Res. 35: 537-540, 2003

Kishida K, Moriwaki M, Miyagawa J, Okita K, Kondo T, Itoh K, Umemura S, Kozawa J, Iwahashi H, Yoshizumi T, Imagawa A, Yamagata K, Maruyama T, Toyoshima T, Kurokawa K, Funahashi T, Matsuzawa Y
Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing' syndrome.
Internal Med 42: 9966-1005, 2003

Li M, Miyagawa J, Moriwaki M, Yuan M, Yang Q, Kozawa J, Yamamoto K, Imagawa A, Iwahashi H, Tochino Y, Yamagata K, Matsuzawa Y
Analysis of expression profiles of islet-associated transcription and growth factors during β-cell neogenesis from duct cells in partially duct-ligated mice.
Pancreas 27: 345-355, 2003

岩橋博見、丸川聡子、松本由美、今川彰久、福井健司、佐山孝一、森脇信、沖田考平、山本浩司、山縣和也、山崎義光、船橋徹、宮川潤一郎、松澤佑次
筋緊張性ジストロフィーのインスリン抵抗性に対するピオグリタゾンの有効性--非肥満患者3例における検討
Diabetes Journal 31:92-96, 2003

山縣和也
MODY
内科キーワード2003 (6月増大号) 内科91 (6): 1413-1414, 2003

山縣和也
糖尿病の遺伝子を探る「HNF遺伝子ファミリー」
Molecular Medicine 40 (1): 96-101, 2003


2002年

Yoshiuchi I, Yamagata K, Zhu Q, Tamada I, Takahashi Y, Onigata K, Takeda J, Miyagawa J, Matsuzawa J
Identification of a gain-of-function mutation in the HNF-1β gene in a Japanese family with MODY.
Diabetologia 45: 153-154, 2002

Yamagata K, Nammo T, Moriwaki M, Ihara A, Iizuka K, Yang Q, Satoh T, Li M, Uenaka R, Okita K, Iwahashi H, Zhu Q, Cao Y, Imagawa A, Tochino Y, Hanafusa T, Miyagawa J, Matsuzawa Y
Overexpression of dominant-negative mutant HNF-1α in pancreatic β-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced β-cell proliferation and diabetes.
Diabetes 51: 114-123, 2002

Nishizawa H, Yamagata K, Shimomura I, Takahashi M, Kuriyama H, Kishida K, Hotta K, Nagaretani H, Maeda N, Matsuda M, Kihara S, Nakamura T, Nishigori H, Tomura H, Moore DD, Takeda J, Funahashi T, Matsuzawa Y
Small heterodimer partner, an orphan nuclear receptor, augments PPAR transactivation.
J. Biol. Chem. 277: 1586-1592, 2002

Iwahashi H, Yamagata K, Yoshiuchi I, Terasaki J, Yang Q, Fukui K, Ihara A, Zhu Q, Asakura T, Cao Y, Imagawa A, Namba M, Hanafusa T, Miyagawa J, Matsuzawa Y
Thyroid hormone receptor interacting protein (Trip3) is a novel coactivator of hepatocyte nuclear factor-4α (HNF-4α).
Diabetes 51: 910-914, 2002

Yang Q, Yamagata K, Fukui K, Cao Yang, Nammo T, Iwahashi H, Wang H, Matsumura I, Hanafusa T, Bucala R, Wollheim CB, Miyagawa J, Matsuzawa Y
Hepatocyte nuclear factor-1α modulates pancreatic β-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells.
Diabetes 51: 1785-1792, 2002

Triggs-Raine BL, Kirkpatrick RD, Kelly SL, Norquay LD, Cattini PA, Yamagata K, Hanley AJ, Zinman B, Harris SB, Barrett PH, Hegele RA
HNF-1α G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community.
Proc Natl Acad Sci U S A 99: 4614-4619, 2002

Nammo T, Yamagata K, Hamaoka R, Zhu Q, Akiyama TE, Gonzalez FJ, Miyagawa J, Matsuzawa Y
Expression profile of MODY3/HNF-1α protein in the developing mouse pancreas.
Diabetologia 45: 1142-1153, 2002

Imagawa A, Funahashi T, Nakamura T, Moriwaki M, Tanaka S, Nishizawa H, Sayama K, Uno S, Iwahashi H, Yamagata K, Miyagawa J, Matsuzawa Y
Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes.
Diabetes Care 25: 1665-1666, 2002

Ming LI, Miyagawa J, Yamamoto K, Moriwaki M, Imagawa A, Iwahashi H, Yamagata K, Tochino Y, Hanafusa T, Matsuzawa Y
β cell neogenesis from ducts and phenotypic conversion of residual islet cells in the adult pancreas of glucose intolerant mice induced selective alloxan perfusion.
Endocrine J. 49: 561-572, 2002

Hara K, Noda M, Waki H, Tobe K, Yamauchi T, Kadowaki H, Satou H, Tsukamoto K, Nagamatsu S, Yamagata K, Matsuzawa Y, Akanuma Y, Kimura S, Kadowaki T
Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4α gene.
Internal Med 41: 848-852, 2002

山縣和也、松澤佑次:MODYと核内レセプター
ホルモンと臨床 Vol.51 春季増刊号「ステロイドホルモン研究の進歩2002」, 48-51, 2002

福井健司、今川彰久、岩橋博見、樫根普、森脇信、南茂隆生、三杉進、関口健二、山縣和也、宮川潤一郎、松澤佑次
急性膵炎後に発症し、膵生検により非自己免疫性劇症1型糖尿病に類似した組織像を認めた糖尿病の1例
糖尿病 45 (10): 759-765, 2002

李銘、山本浩司、森脇 信、袁 明、南茂隆生、今川彰久、岩橋博見、山縣和也、栩野義博、宮川潤一郎、松澤佑次
導管部分結紮マウスにおける導管細胞から 細胞への新生
Diabetes Frontier 13(5):678, 2002

山縣和也
核内受容体ネットワークによるインスリン分泌能・感受性の調節
内分泌・糖尿病科 15 (6): 590-593, 2002

山縣和也
《糖尿病の成因・病態への新しい視点》転写因子病としての糖尿病
内科 91(1): 59-62, 2003

山縣和也
膵 細胞転写因子 知っておきたい200words-現代医学理解のために
医学のあゆみ 200(13) 1182-1183, 2002 医師薬出版株式会社

山縣和也
転写因子によるβ細胞機能の調節
糖尿病ナビゲーター pp24-25 編集:門脇孝 メヂィカルレビュー社2002


2001年

Nishigori H, Tomura H, Tonooka N, Kanamori M, Yamada S, Sho K, Inoue I, Kikuchi N, Onigata K, Kojima I, Kohama T, Yamagata K, Yang Q, Matsuzawa Y, Miki T, Seino S, Kim Mi-Y, Choi H-S, Lee Y-W, Moore DD, Takeda J
Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese.
Proc. Natl. Acad. Sci. USA 98: 575-580, 2001

Zhu Q, Yamagata K, Tsukahara Y, Yang Q, Liu W, Hanafusa T, Miyagawa J, Matsuzawa Y
Mutation screening of the hepatocyte nuclear factor (HNF)-6 gene in Japanese subjects with diabetes mellitus.
Diabetes Res Clin Pract 52: 171-174, 2001

Imagawa A, Hanafusa T, Tamura S, Moriwaki M, Itoh N, Yamamoto K, Iwahashi H, Yamagata K, Waguri M, Nammo T, Uno S, Nakajima H, Namba M, Kawata S, Miyagawa J, Matsuzawa Y
Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes mellitus-Close correlation between serological markers and histological evidence of cellular autoimmunity-.
Diabetes 50: 1269-1273, 2001

Mori H, Ikegami H, Kawaguchi Y, Seino S, Yokoi N, Takeda J, Inoue I, Seino Y, Yasuda K, Hanafusa T, Yamagata K, Awata T, Kadowaki T, Hara K, Yamada N, Gotoda T, Iwasaki N, Iwamoto Y, Sanke T, Nanjo K, Oka Y, Matsutani A, Maeda E, Kasuga M
The Pro12 --Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.
Diabetes 50: 891-894, 2001

Yoshiuchi I, Yamagata K, Yoshimoto M, Zhu Q, Yang Q, Nammo T, Uenaka R, Kinoshita E, Hanafusa T, Miyagawa J, Matsuzawa Y
A non-functional HNF-1α mutation in Japanese subjects with familial type 1 diabetes.
Human Mutation 18: 345-351, 2001


2000年以前

Yamada S, Zhu Q, Aihara Y, Onda H, Zhang Z, Yu L, Jin L, Si Y, Nishigori H, Tomura H, Inoue I, Morikawa A, Yamagata K, Hanafusa T, Matsuzawa Y, Takeda J
Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3β and mutation screening in Japanese subjects with MODY.
Diabetologia 43: 121-124, 2000

Yang Q, Yamagata K, Yamamoto K, Cao Y, Miyagawa J, Fukamizu A, Hanafusa T, Matsuzawa Y
R127-HNF-4α is a loss of function mutation but not a rare polymorphism and causes Type II diabetes in a Japanese family with MODY1.
Diabetologia 43: 520-524, 2000.

Zhu Q, Yamagata K, Yu L, Tomura H, Yamada S, Yang Q, Yoshiuchi I, Sumi S, Miyagawa J, Takeda J, Hanafusa T, Matsuzawa Y
Identification of missense mutations in the hepatocyte nuclear factor-3β gene in Japanese subjects with late-onset type 2 diabetes mellitus.
Diabetologia 43: 1197-1200, 2000

Takahashi M, Arita Y, Yamagata K, Matsukawa Y, Okutomi K, Horie M, Shimomura I, Hotta K, Kuriyama H, Kihara S, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y
Genomic structure and mutations in adipose-specific gene, adiponectin.
International Journal of Obesity 24: 861-868, 2000.

Yamamoto K, Miyagawa J, Waguri M, Sasada R, Igarashi K, Li M, Nammo T, Moriwaki M, Imagawa A, Yamagata K, Nakajima H, Namba M, Tochino Y, Hanafusa T, Matsuzawa Y
Recombinant human betacellulin promotes the neogenesis of β-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion.
Diabetes 49: 2021-2027, 2000

山縣和也
糖尿病・肥満
血管医学1(2): 73-84, 2000

山縣和也
Maturity-onset diabetes of the young (MODY)
最新医学2000

山縣和也、松澤佑次
転写因子による 細胞機能の調節とその異常
医学のあゆみ 192(5): 326-329, 2000

山縣和也、松澤佑次
HNF異常と糖尿病
月刊薬事42(4): 1129-1133, 2000

山縣和也、花房俊昭、松澤佑次
糖尿病と転写因子
現代医療32(2):423-430, 2000


1999年

Yoshiuchi I, Yamagata K, Yang Q, Iwahashi H, Okita K, Yamamoto K, Oue T, Imagawa A, Hamaguchi T, Yamasaki T, Horikawa Y, Satoh T, Nakajima H, Miyazaki J, Higashiyama S, Miyagawa J, Namba M, Hanafusa T, Matsuzawa Y
Three new mutations in the hepatocyte nuclear factor-1α gene in Japanese subjects with diabetes mellitus: Clinical features and functional characterization.
Diabetologia 42: 621-626, 1999

Imagawa A, Hanafusa T, Itoh N, Waguri M, Yamamoto K, Miyagawa J, Moriwaki M, Yamagata K, Iwahashi H, Sada M, Tsuji T, Tamura S, Kawata S, Kuwajima M, Nakajima H, Namba M, Matsuzawa Y
In situ immunological abnormalities in islets paralleled further deterioration of glycemic control in recent-onset type 1 (insulin-dependent) diabetes mellitus patients.
Diabetologia 42: 574-578, 1999

Iwahashi H, Hanafusa T, Imagawa A, Tomita K, Moriwaki M, Yamamoto K, Waguri M, Yamagata K, Itoh N, Yoshiuchi I, Nanmo T, Nakajima H, Miyagawa J, Namba M, Matsuzawa Y
Emerging therapeutic strategies in autoimmune diabetes: aetiology, prediction, prevention and cure.
Emerging Therapeutic Targets 3: 177-193, 1999

Tomura H, Nishigori H, Sho K, Yamagata K, Inoue I, Takeda J
Loss-of-function and dominant-negative mechanisms associated with hepatocyte nuclear factor-1β mutations in familial type 2 diabetes mellitus.
J. Biol. Chem. 274: 12975-12978, 1999

Moriwaki M, Itoh N, Miyagawa J, Yamamoto K, Imagawa A, Yamagata K, Iwahashi H, Nakajima H, Namba M, Kuwajima M, Nagata S, Hanafusa T, Matsuzawa Y
Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type 1 diabetes mellitus.
Diabetologia 42: 1332-1340, 1999

Okita K, Yang Q, Yamagata K, Hangenfeldt KA, Miyagawa J, Kajimoto Y, Nakajima H, Namba M, Wollheim CB, Hanafusa T, Matsuzawa Y
Human insulin gene is a target of hepatocyte nuclear factor-1α (HNF-1α) and HNF-1α.
Biochem. Biophys. Res. Commun. 263: 566-569, 1999

Yang Q, Yamagata K, Yamamoto K, Miyagawa J, Takeda J, Iwasaki N, Iwahashi H, Yoshiuchi I, Namba M, Miyazaki J, Hanafusa T, Matsuzawa Y
Structure/function studies of hepatocyte nuclear factor-1α, a diabetes-associated transcription factor.
Biochem. Biophys. Res. Commun. 266: 196-202, 1999

楊勤、山縣和也、沖田孝平、山本浩司、岩橋博見、吉内一正、山本浩司、難波光義、宮川潤一郎、花房俊昭、松澤佑次
分子糖尿病学
Molecular Diabetology 1999 vol10, p93-96, 分子糖尿病研究会編、医歯薬出版1999

山縣和也、花房俊昭、松澤佑次
MODYの分類と遺伝子異常
小児内科31(9):1282-1284, 1999

山縣和也、松澤佑次
MODY-HNFカスケードの異常による糖尿病
医学のあゆみ 187(7) 477-481, 1999

伊藤直人、山縣和也
糖尿病 慢性合併症ー神経障害ー
総合内科診断学 p517-519 垂井清一郎総編集、松澤佑次・河田純男編集 朝倉書店 1999

山縣和也、松澤佑次
MODYの遺伝解析とその病態
糖尿病学の進歩' 99 第33集p130-136 日本糖尿病学会編 診断と治療社 1999

山縣和也、松澤佑次
HNF-4 の内因性リガンド
内分泌・糖尿病科 9(2): 152-154, 1999

山縣和也、花房俊昭、松澤佑次
HNF異常型糖尿病
細胞工学 18(2): 254-258, 1999


1998年

Iwahashi H, Itoh N, Yamagata K, Imagawa A, Nakajima H, Tomita K, Moriwaki K, Waguri M, Yamamoto K, Miyagawa J, Namba M, Hanafusa T, Matsuzawa Y
Molecular mechanisms of pancreatic beta-cell destruction in autoimmune diabetes: Potential targets for preventive therapy.
Cytokines, Cellular & Molecular Therapy 4: 45-51, 1998

Yamagata K, Yang Q, Yamamoto K, Iwahashi H, Miyagawa J, Okita K, Yoshiuchi I, Miyazaki J, Noguchi T, Nakajima H, Namba M, Hanafusa T, Matsuzawa Y
Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1α is dominant negative.
Diabetes 47: 1231-1235, 1998

Miyagawa J, Yamamoto K, Li M, Sasada R, Igarashi K, Nanmo T, Kitajima K, Moriwaki M, Yamagata K, Nakajima H, Namba M, Hanafusa T, Matsuzawa Y
Duct cell proliferation in the process of islet cell neogenesis induced by betacellulin -Study on the diabetic mice induced by selective alloxan perfusion-.
Endocrinologia 45: 274-275, 1998

山縣和也、花房俊昭
II型糖尿病
Molecular Medicine vol 35臨時増刊号 症候・病態の分子メカニズム p439-441松澤佑次総編集 中山書店 1998

山縣和也、松澤佑次
成人病にかかわる遺伝子異常 糖尿病とHNF (Hepatocyte nuclear factor)
診断と治療 86(12): 2093-2098, 1998

山縣和也: 基礎講座I Molecular Genetics
発現地図の作成と遺伝子単離
Diabetes Frontier 9(6): 765-769, 1998

山縣和也、松澤佑次
Hepatocyte nuclear factor (HNF)の生物学的意義
内分泌・糖尿病科 7(4): 347-351, 1998

山縣和也、松澤佑次
Maturity-onset diabetes of the young (MODY) 関連遺伝子
内科 82(5): 865-869, 1998

山縣和也、松澤佑次
MODY1, 3
糖尿病学の進歩'98 第32集 p182-188 日本糖尿病学会編  診断と治療社 1998年

山縣和也、花房俊昭、松澤佑次
HNF-1 , HNF-4 とMODY
分子糖尿病学の進歩-基礎から臨床まで-1998 p78-83 (監修:矢崎義雄) 金原出版 1998年 

山縣和也、花房俊昭、松澤佑次
MODYの発症機構
BIO Clinica 13(4): 300-305, 1998

山本浩司、宮川潤一郎、佐々田玲子、五十嵐貢一、山縣和也、中島弘、難波光義、花房俊昭、松沢佑次
Betacellulin ノックアウトマウスにおける耐糖能の変化および膵内分泌細胞の形態学的分析
Diabetes Frontier 9 (3): 362, 1998

山縣和也、楊 勤、吉内一正、花房俊昭、松澤佑次
HNF遺伝子異常とMODYの発症
MEDICO 29(6): 12812-12816, 1998

吉内一正、山縣和也、花房俊昭、松澤佑次
糖尿病遺伝子はどこまで明らかにされたか
Medical Practice 15(1): 106-107, 1998


1997年

Kaisaki PJ, Menzel S, Linder T, Oda N, Rjasanowski I, Sahm J, Meincke G, Schulze J, Schmechel H, Petzold C, Ledermann HM, Sachse G, Boriraj VV, Menzel R, Kerner W, Turner RC, Yamagata K, Bell GI
Mutations in the hepatocyte nuclear factor-1 gene in MODY and early-onset NIDDM: Evidence for a mutational hotspot in exon 4.
Diabetes 46: 528-535, 1997.

Vaxillaire M, Rouard M, Yamagata K, Oda N, Kaisaki PJ, Boriraj VV, Chevre J-C, Boccio V, Cox RD, Lathrop GM, Dussoix P, Philippe J, Timsit J, Charpentier G,Velho G, Bell GI, Froguel P
Identification of nine novel mutations in the hepatocyte nuclear factor1 alpha gene associated with maturity-onset diabetes of the young (MODY3).
Hum Mol Gen 6: 583-586, 1997.

Urhammer SA, Rasmussen SK, Kaisaki PJ, Oda N, Yamagata K, Moller AM, Fridberg M, Hansen L, Hansen T, Bell GI, Pedersen O
Genetic variation in the hepatocyte nuclear factor-1α gene in Danish Caucasians with late-onset NIDDM.
Diabetologia 40: 473-475, 1997.

Frayling T, Bulman M, Ellard S, Appleton M, Dronsfield MJ, Mackie ADR, Baird JD, Kaisaki PJ, Yamagata K, Bell GI, Bain SC, Hattersley AT
Mutations in the hepatocyte nuclear factor-1α gene are a common cause of maturity-onset diabetes of the young in the United Kingdom.
Diabetes 46: 720-725, 1997.

Iwasaki N, Oda N, Ogata M, Hara M, Hinokio Y, Oda Y, Yamagata K, Kanematsu S, Ohgawara H, Omori Y, Bell GI
Mutations in the hepatocyte nuclear factor-1α /MODY3 gene in Japanese subjects with early- and late-onset NIDDM.
Diabetes 46: 1504-1508, 1997.

Furuta H, Iwasaki N, Oda N, Hinokio Y, Horikawa Y, Yamagata K, Yano N, Sugahiro J, Ogata M, Ohgawara H, Omori Y, Iwamoto Y, Bell GI
Organization and partial sequence of the hepatocyte nuclear factor-4α/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY.
Diabetes 46: 1652-1657, 1997.

Horikawa Y, Iwasaki N, Hara M, Furuta H, Hinokio Y, Cockburn BN, Lindner T, Yamagata K, Ogata M, Tomonaga O, Kuroki H, Kasahara T, Iwamoto Y, Bell GI
Mutation in hepatocyte nuclear factor-1β gene (TCF2) associated with maturity-onset diabetes of the young.
Nature Genet. 17: 384-385, 1997

楊 勤、吉内一正、山縣和也、岩橋博見、山本浩司、宮川潤一郎、宮崎純一、中島 弘、難波光義、花房俊昭、松澤佑次
分子糖尿病学 Molecular Diabetology 1997

山縣和也、花房俊昭、松澤佑次
インスリン非依存型糖尿病遺伝子探索の最近の現況
Diabetes Journal 25(4): 153-159, 1997

山縣和也、岩崎直子、Graeme I. Bell
NIDDM1遺伝子座の同定
分子糖尿病学の進歩-基礎から臨床まで-1997 p77-81 (監修:矢崎義雄) 金原出版 1997年 

山縣和也、松沢佑次
遺伝子の変異と疾患の発症
medicina 34(12): 2086-2088, 1997

山縣和也、松澤佑次
Maturity-onset diabetes of the young (MODY)
別冊・医学の歩み 内分泌・代謝疾患-state of arts p465-466 (編集:赤沼安夫、藤田敏郎、門脇孝) 医歯薬出版株式会社 1997年

山縣和也、松澤佑次
MODY発症遺伝
山縣和也、松澤佑次: 遺伝子の変異と疾患の発症
medicina 34(12): 2086-2088, 1997子研究の新展開 最新医学 52(10): 2393-2397, 1997

古田耕人、山縣和也、織田直久、岩崎直子、Graeme I. Bell
MODY1, MODY3遺伝子の同定
内分泌・糖尿病科 5(4): 318-324, 1997

山縣和也、織田直久、古田耕人、Graeme I. Bell
若年発症成人型糖尿病(MODY)の原因遺伝子HNFは糖尿病発症にどうかかわるのか
実験医学 15(6): 642-644, 1997


1996年

Iwasaki N, Kawamura M, Yamagata K, Cox NJ, Karibe S, Ohgawara H, Inagaki N, Seino S, Bell GI, Omori Y
Identification of microsatellite markers near the human genes encoding the β-cell ATP-sensitive potassium channel and linkage studies with NIDDM in Japanese.
Diabetes 45: 267-269, 1996.

Gambino V, Menzel S, Trabb JB, Xiang KS, Lindner T, Louit A, Chen E, Mereu LE, Furuta H, Iwasaki N, Kawamura M, Omori Y, Rietzsch H, Schulze J, Schr?der HE, Concannon P, Hanis CL, Spielman RS, Yamagata K, Cox NJ, Bell GI
An approach for identifying simple sequences repeat DNA polymorphisms near cloned cDNAs and genes: linkage studies of the islet amyloid polypeptide/amylin and liver glycogen synthase genes and NIDDM.
Diabetes 45: 291-294, 1996.

Yamagata K, Takeda J, Menzel S, Chen X, Eng S, Lim LR, Concannon P, Hanis CL, Spielman RS, Cox NJ, Bell GI
Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle.
Diabetologia 39: 725-730, 1996.

Hanis CL, Boerwinkle E, Chakraborty R, Ellsworth DE, Concannon P, Stirling B, Morrison VA, Wapelhorst B, Spielman RS, Gogolin-Ewens KJ, Shephard JM, Williams SR, Risch N, Hinds D, Iwasaki N, Ogata M, Omori Y, Petzold C, Rietzsch H, Schr?der HE, Schulze J, Cox NJ, Menzel S, Boriraj VV, Chen X, Lim LR, Lindner T, Mereu LE, Wang YQ, Xiang KS, Yamagata K, Yang Y, Bell GI
A genome-wide search for human non-insulin-dependent (Type 2) diabetes mellitus susceptibility genes: evidence for a major susceptibility locus on chromosome 2.
Nature Genet. 13: 161-166, 1996.

Yamagata K, Nakajima H, Tomita K, Itoh N, Miyagawa JI, Hamaguchi T, Namba M, Tamura S, Kawata S, Kono N, Kuwajima M, Noguchi T, Hanafusa T, Matsuzawa Y
Dominant TCR α-chain clonotypes and interferon-γ are expressed in the pancreas of patients with recent-onset insulin-dependent diabetes mellitus.
Diabetes Res. Clin. Pract. 34: 37-46, 1996.

Byrne MM, Sturis J, Menzel S, Yamagata K, Fajans SS, Dronsfield MJ, Bain SC, Hattersley AT, Velho G, Froguel P, Bell GI, Polonsky KS
Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes mellitus susceptibility gene MODY3 on chromosome 12q.
Diabetes 45: 1503-1510, 1996.

Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, Southam L, Cox RD, Lathrop GM, Boriraj VV, Chen X, Cox NJ, Oda Y, Yano H, Le Beau MM, Yamada S, Nishigori H, Takeda J, Fajans SS, Hattersley AT, Iwasaki N, Hansen T, Pedersen O, Polonsky KS, Turner RC, Velho G, Chevre J-C, Froguel P, Bell GI
Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3).
Nature 384: 455-458, 1996

Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M, Bell GI
Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1).
Nature 384: 458-460, 1996


1995年

Takeda J, Fernald AA, Yamagata K, Le Beau MM, Bell GI
Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization.
Genomics 26: 638-639, 1995.

El-Maghrabi MR, Lang AJ, Jiang W, Yamagata K, Stoffel M, Takeda J, Fernald AA, Le Beau MM, Bell GI, Baker L, Pilkis SJ
Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency.
enomics 27: 520-525, 1995.

Itoh N, Hanafusa T, Yamagata K, Nakajima H, Tomita K, Tamura S, Inada M, Kawata S, Kono N, Kuwajima M, Matsuzawa Y
No detectable cytomegalovirus and Epstein-Barr virus genomes in the pancreas of recent-onset IDDM patients.
Diabetologia 38:667-671, 1995.

Menzel S, Yamagata K, Trabb JB, Nerup J, Permutt MA, Fajans SS, Menzel R, Iwasaki N, Omori Y, Cox NJ, Bell GI
Localization of MODY3 to a 5 cM region of human chromosome 12.
Diabetes 44: 1408-1413, 1995.

山縣和也、中島弘、花房俊昭
T細胞レセプター
細胞工学別冊「医学実験マニュアルシリーズ」糖尿病研究ストラテジー 47-55, 1995 秀潤社

花房俊昭、山縣和也、中島 弘、桑島正道、松沢佑次
IDDM患者膵島浸潤T細胞のTCR: 生検膵組織を用いた検討
糖尿病記録号 1994(島 健二編): 258-259, 1995(医学図書出版)

中島 弘、伊藤直人、山縣和也、冨田晃司、花房俊昭、桑島正道、松沢佑次
IDDMにおけるウイルスの関与-環境要因の分子生物学的検討-
糖尿病記録号 1994(島 健二編): 260-262, 1995(医学図書出版)


1994年

冨田晃司、中島弘、花房俊昭、宮川潤一郎、岩橋博見、山縣和也、浜口朋也、桑島正道、松澤佑次、河野典夫、田中武彦、野口民夫
NODマウス膵に発現するレトロウイルスの全遺伝子構造の解析
分子糖尿病学1994 (5): 131-133 分子糖尿病学研究会編 医学図書出版 1994

山縣和也、中島弘、花房俊昭、冨田晃司、伊藤直人、桑島正道、松澤佑次
発症早期インスリン依存型糖尿病(IDDM)患者生検膵における浸潤T細胞レセプターの遺伝子解析
インスリン研究1994 (16): 63064, 1994

山縣和也、花房俊昭、中島弘、冨田晃司、伊藤直人、田村信司、河田純男、河野典夫、桑島正道、松澤佑次
発症早期インスリン依存型糖尿病(IDDM)患者生検膵における浸潤T細胞レセプターの遺伝子解析
糖尿病記録号 1993: 235-238, 1994

花房俊昭、山縣和也、中島弘
IDDM膵における浸潤T細胞レセプター遺伝子の解析
日本臨床 52(10): 2767-2771, 1994

花房俊昭、山縣和也、中島弘
インスリン依存型糖尿病患者の膵臓における浸潤T細胞レセプター遺伝子の解析
炎症と免疫 2(2): 138-144, 1994


1993年

Nakajima H, Hamaguchi T, Tomita K, Uenaka R, Yamagata K, Hanafusa T, Kuwajima M, Noguchi T, Tanaka T, Kono N, Matsuzawa Y
An alternate nonisotopic technique of PCR-mediated allele-specific oligonucleotide analysis for the detection of a point mutation.
Res. Commun. Chem. Pathol. Pharmacol. 79: 3-10, 1993

Yamagata K, Hanafusa T, Nakajima H, Sato T, Noguchi T, Tomita K, Tsuji K, Kono N, Tanaka T, Tarui S, Kuwajima M, Inoko H, Matsuzawa Y
Overexpression of HLA class 1 antigen reduces insulin secretion in pancreatic βcells (RINm5F): Evidence for a non immune mechanism.
Res. Commun. Chem. Pathol. Pharmacol. 81: 299-308, 1993.

Itoh N, Hanafusa T, Miyazaki A, Miyagawa J, Yamagata K, Yamamoto K, Waguri M, Imagawa A, Tamura S, Inada M, Kawata S, Tarui S , Kono N, Matsuzawa Y
Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.
J. Clin. Invest. 92: 2313-2322, 1993.

今川彰久、伊藤直人、花房俊昭、宮崎厚、三木啓之、宮川潤一郎、山縣和也、和栗雅子、田村信司、難波光義、河田純男、桑島正道、河野典夫、松沢佑次
CD8+Tリンパ球主体の膵島炎を認めたインスリン依存型糖尿病の一例 -生検膵組織における検討-
糖尿病、36(11)、875-880、1993

河野典夫、花房俊昭、和栗雅子、伊藤直人、山縣和也、中島 弘、宮川潤一郎
患者膵島病変の分析によるIDDM成因の解明
厚生省「糖尿病調査研究」平成4年度報告書 糖尿病の発症機序に関する研究: 168-172, 1993


1992年

山縣和也、花房俊昭
IDDMの成因分析
最近の進歩
Pharma Medica 10(8): 27-31, 1992


1991年

Yamagata K, Hanafusa T, Nakajima H, Sada M, Amemiya H, Noguchi T, Tanaka T, Kono N, Tarui S
HLA-DQA1*1 contributes to resistance and A1*3 confers susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.
Diabetologia 34: 133 136, 1991.

Yamagata K, Hanafusa T, Nakajima H, Sada M, Amemiya H, Tomita K, Miyagawa J, Noguchi T, Tanaka T, Kono N, Tarui S
HLA-DP and susceptibility to insulin-dependent diabetes mellitus in Japanese.
Tissue Antigens 38: 107-110, 1991.

Noguchi T, Yamada K, Yamagata K, Takenaka M, Nakajima H, Imai E, Wang Z, Tanaka T
Expression of liver type pyruvate kinase in insulinoma cells: Involvement of LF-B1 (HNF1).
Biochem. Biophys. Res. Commun. 181: 259-264, 1991.

伊藤直人、花房俊昭、宮川潤一郎、田村信司、稲田正己、桂 勇人、山縣和也、河田純男、河野典夫、垂井清一郎
インスリン依存型糖尿病(IDDM)発症における細胞接着分子ICAM-1とLFA-3の役割 -生検膵組織血管内皮細胞における検討-
Peptide Hormones in Pancreas、11、103-106、1991

山縣和也、花房俊昭、中島弘、河野典夫、垂井清一郎
日本人インスリン依存型糖尿病患者のHLA-DQA, DQB, TNF遺伝子の解析
分子糖尿病学2: 13-17, 1991

山縣和也、花房俊昭、河野典夫
DQ遺伝子とIDDM
Diabetes J. 19(3): 85-91, 1991

山縣和也、花房俊昭
インスリン依存型糖尿病とMHC
日本臨床 49(増刊):525-530, 1991

山縣和也、花房俊昭
自己免疫性内分泌疾患の病因: MHC
Pharma Medica 9(5): 43-48, 1991

山縣和也、花房俊昭
Q & A
Diabetes Frontier 2(5): 629, 1991

山縣和也、花房俊昭、宮川潤一郎、河野典夫、垂井清一郎
IDDMの成因と分子生物学
総論 Diabetes Frontier 2(1): 29-33, 1991

桂勇人、宮川潤一郎、渡辺伸明、小松良哉、藤井宏、中川智左、山本浩司、山縣和也、津川真美子、伊藤秀彦、田島幸児、難波光義、花房俊昭、河野典夫、森脇要、垂井清一郎
胸腺カルチノイドとMEN type1を合併し、ソマトスタチンアナログ(SMS201-995)による治療を試みた1症例
ホルモンと臨床 39: 292-295, 1991

花房俊昭、山縣和也
サイトカインによる内分泌細胞MHC遺伝子発現調節
自己免疫性内分泌疾患の発症における重要性 公益信託加藤記念難病研究助成基金助成研究報告書 3: 17-24, 1991


1990年

Yamagata K, Hanafusa T, Nakajima H, Miyagawa J, Miyazaki A, Kono N, Tarui S
Expression of MHC antigens on islet cells in insulin-dependent diabetes mellitus: Analysis of pancreas biopsy specimens and RINm5F cells.
Recent trends of diabetes mellitus in East Asia (G. Mimura, C.Zhisheng eds.): 73-76, 1990 (Elsevier Science Pub., Amsterdam).

Kiyokawa H, Namba M, Miyazaki A, Yamagata K, Tajima K, Miyagawa J, Kono N, Tarui S
Nocturnal increase in urinary epinephrine excretion in IDDM treated with intensive insulin therapy: A clinical indicator of asymptomatic hypoglycemia.
Current Proc. 3rd Int. Symp. Treatment of Diabetes Mellitus (N.Sakamoto, K.G.M.M. Alberti, N. Hotta eds): 681-685, 1990 (Elsevier Science Pub., Amsterdam).

Hanafusa T, Miyazaki A, Miyagawa J, Tamura S, Inada M, Yamada K, Shinji Y, Katsura H, Yamagata K, Itoh N, Asakawa H, Nakagawa C, Otsuka A, Kawata S, Kono N, Tarui S
Examination of islets in the pancreas biopsy specimens from newly diagnosed Type 1 (insulin-dependent) diabetic patients.
Diabetologia 33: 105-111, 1990.

Miyagawa J, Yamamoto K, Hanafusa T, Itoh N, Nakagawa C, Otsuka A, Katsura H, Yamagata K, Miyazaki A, Kono N, Tarui S
Preventive effect of a new immuno suppressant FK-506 on insulitis and diabetes in non-obese diabetic mice.
Diabetologia 33:503-505, 1990.

Asakawa H, Miyagawa J, Hanafusa T, Katsura H, Miyazaki A, Otsuka A, Nakagawa C, Yamagata K, Tajima K, Mashita K, Kono N, Tarui S
Interferon-γ reduces actin filaments and inhibits thyroid-stimulating hormone-induced formation of microvilli and pseudopods in mouse monolayer thyrocytes. Endocrinology 127: 325-329, 1990.

山縣和也、花房俊昭
インスリン依存型糖尿病の成因
日本臨床臨時増刊号 臨床免疫(下巻)48: 426-430, 1990

山縣和也、花房俊昭、中島弘、河野典夫、垂井清一郎
日本人IDDMのHLAクラスII遺伝子の解析
分子糖尿病学1990 vol1, p27-30 分子糖尿病学研究会編 医学図書出版 1990

宮川潤一郎、山本浩司、花房俊昭、桂勇人、伊藤直人、中川智左、山縣和也、河野典夫、垂井清一郎
NODマウスの膵島炎発現と糖尿病発症に対する免疫抑制剤FK-506の効果
糖尿病動物4 p205-210, 糖尿病動物研究会編 医歯薬ジャーナル 1990


1989年

Yamagata K, Nakajima H, Hanafusa T, Noguchi T, Miyazaki A, Miyagawa J, Sada M, Amemiya H, Tanaka T, Kono N, Tarui S
Aspartic acid at position 57 of DQβ chain does not protect against Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.
Diabetologia 32: 762-764, 1989.

1988年

宮川潤一郎、花房俊昭、宮崎厚、桂勇人、朝川秀樹、大塚章人、中川智左、山縣和也、伊藤直人、河野典夫、垂井清一郎、栩野義博
インスリン治療による長期生存NODマウスにおける糖尿病性糸球体病変
糖尿病動物2 p190-194, 後藤由夫編 医歯薬ジャーナル 1988

 
 
 
 
 
 
 
 
 
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熊本市本荘1丁目1番1号
熊本大学大学院生命科学研究部 病態生化学講座

TEL: 096-373-5070 (受付)
FAX: 096-364-6940

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